Fast and Selective Dehydrogenative C-H/C-H Arylation Using Niechanochemistry

被引：102

作者：

Lou, Shao-Jie ^{[1
]}

Mao, Yang-Jie ^{[1
]}

Xu, Dan-Qian ^{[1
]}

He, Jiang-Qi ^{[1
]}

Chen, Qi ^{[1
]}

Xu, Zhen-Yuan ^{[1
]}

机构：

[1] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Catalyt Hydrogenat Res Ctr, Hangzhou 310014, Zhejiang, Peoples R China

来源：

ACS CATALYSIS | 2016年 / 6卷 / 06期

基金：

中国博士后科学基金;

关键词：

mechanochemistry; C-H bond activation; selective arylation; biaryls; ball milling; CATALYZED ORTHO-ARYLATION; ARYL BOND FORMATION; COUPLING REACTIONS; BENZAMIDES; ARENES; FUNCTIONALIZATION; MECHANOCHEMISTRY; ACTIVATION; AMIDATION; AZIDES;

D O I：

10.1021/acscatal.6b00861

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A fast and site-selective biaryl synthesis via dehydrogenative C-H/C-H arylation in a ball mill was developed. In this paper, both electron-deficient oximes and electron-rich anilides quickly and under mild conditions provided arylation with various arenes to give the biaryl products in high-level selectivity. Given the solventless mechanochemical conditions, the transformation obviated the use of large amounts of arene coupling partners as solvents and allowed utilization of more-complicated and more-expensive arenes as coupling partners, which may dramatically enhance the application prospect of the C-H/C-H arylation strategy.

引用

页码：3890 / 3894

页数：5

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