ARP3 promotes tumor metastasis and predicts a poor prognosis in hepatocellular carcinoma

被引：7
|
作者：
Lv, Jiale [1 ]
Liu, Jinxia [1 ]
Xiao, Mingbin [1 ,2 ]
Xu, Hui [1 ]
Xu, Chenzhou [1 ]
Zhang, Xuening [1 ]
Tang, Lei [1 ]
Jiang, Feng [1 ,2 ]
Zhou, Yifan [3 ]
Zhang, Zijuan [1 ]
Qu, Lishuai [1 ]
Lu, Cuihua [1 ]
机构：
[1] Nantong Univ, Affiliated Hosp, Dept Gastroenterol, Nantong 226001, Jiangsu, Peoples R China
[2] Nantong Univ, Affiliated Hosp, Res Ctr Clin Med, Nantong 226001, Jiangsu, Peoples R China
[3] Nantong Univ, Med Coll, Clin Med, Class 4,Grade 14, Nantong 226001, Jiangsu, Peoples R China
来源：
PATHOLOGY RESEARCH AND PRACTICE | 2018年 / 214卷 / 09期
基金：
中国国家自然科学基金;
关键词：
ARP3; Hepatocellular carcinoma; Prognosis; Metastasis; RISK-FACTORS; PREVENTION; PERSPECTIVES; MANAGEMENT; MOTILITY; INVASION; CELLS;
D O I：
10.1016/j.prp.2018.05.028
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. Therefore, the study of the precise molecular mechanism underlying hepatocarcinogenesis has profound significance. In this study, we found that the expression of ARP3 was significantly up-regulated in HCC tissues and cell lines. Studies in liver cancer specimens showed that the expression of ARP3 is closely related to the pathological grade, distant metastasis and vascular invasion of HCC. According to the results of multivariate analysis, ARP3 is an independent prognostic factor for HCC patients. In vitro, knockdown of ARP3 expression significantly inhibited the invasion and migration of HCC cells and altered the expression of EMT markers. Based on the above conclusions, we conclude that ARP3 may be a potential prognostic indicator and therapeutic target for HCC patients.
引用
收藏
页码：1356 / 1361
页数：6
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