LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST

被引：46
|
作者：
Cunha, Vanessa R. R. [1 ]
Ferreira, Ana Maria da C. [1 ]
Constantino, Vera R. L. [1 ]
Tronto, Jairo [2 ]
Valim, Joao B. [3 ]
机构：
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05513970 Sao Paulo, Brazil
[2] Univ Fed Vicosa, BR-38810000 Rio Paranaiba, MG, Brazil
[3] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP, Brazil
来源：
QUIMICA NOVA | 2010年 / 33卷 / 01期
关键词：
layered double hydroxides; inorganic carriers; drug release; IN-VITRO RELEASE; DRUG-DELIVERY SYSTEM; ANIONIC CLAYS; COMPUTER-SIMULATION; MULTIFUNCTIONAL NANOPARTICLES; INTERCALATION COMPOUNDS; SUSTAINED-RELEASE; HYBRID MATERIALS; LDH NANOHYBRID; AMINO-ACIDS;
D O I：
10.1590/S0100-40422010000100029
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
LAYERED DOUBLE HYDROXIDES: INORGANIC NANOPARTICLES FOR STORAGE AND RELEASE OF SPECIES OF BIOLOGICAL AND THERAPEUTIC INTEREST. Studies about the inorganic nanoparticles applying for non-viral release of biological and therapeutic species have been intensified nowadays. This work reviews the preparation strategies and application of layered double hydroxides (LDH) as carriers for storing, carrying and control delivery of intercalated species as drugs and DNA for gene therapy. LDH show low toxicity, biocompatibility, high anion exchange capacity, surface sites for functionalization, and a suitable equilibrium between chemical stability and biodegradability. LDH can increase the intercalated species stability and promote its sub-cellular uptake for biomedical purposes. Concerning the healthy field, LDH have been evaluated for clinical diagnosis as a biosensor component.
引用
收藏
页码：159 / 171
页数：13
相关论文
共 50 条
  • [1] Inorganic layered double hydroxides as nonviral vectors
    Choy, JH
    Kwak, SY
    Jeong, YJ
    Park, JS
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2000, 39 (22) : 4042 - 4045
  • [2] Inorganic layered double hydroxides as nonviral vectors
    Choy, Jin-Ho
    Kwak, Seo-Young
    Jeong, Yong-Joo
    Park, Jong-Sang
    Angewandte Chemie (International Edition in English), 2000, 39 (22): : 4042 - 4045
  • [3] Calcined layered double hydroxides as a "biomolecular vessel" for bromelain: Immobilization, storage and release
    Shi, Wenying
    Wei, Min
    Jin, Lan
    Li, Congju
    JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2007, 47 (1-2) : 58 - 65
  • [4] Inorganic layered double hydroxides as a drug delivery system - intercalation and in vitro release of fenbufen
    Li, BX
    He, J
    Evans, DG
    Duan, X
    APPLIED CLAY SCIENCE, 2004, 27 (3-4) : 199 - 207
  • [5] Layered double hydroxides for controlled fluoride release
    Cardoso, Clarissiane Serafim
    de Freitas, Johnnatan Duarte
    Lima dos Santos, Naile Roberta
    Almeida, Alexandre, Jr.
    Basilio, Irinaldo Diniz, Jr.
    do Nascimento, Ticiano Gomes
    Meireles Grillo, Luciano Aparecido
    Celerino de Moraes Porto, Isabel Cristina
    Gomes Marinho, Jose Luis
    de Souza dos Santos, Grazielle Emanuella
    Meili, Lucas
    Sampaio, Fabio Correia
    Dornelas, Camila Braga
    BRAZILIAN ORAL RESEARCH, 2021, 35
  • [6] LAYERED DOUBLE HYDROXIDES FOR ANION CAPTURE AND STORAGE
    Phillips, J.
    Vandeperre, L. J.
    CERAMIC MATERIALS FOR ENERGY APPLICATIONS, 2011, 32 (09): : 33 - 39
  • [7] Layered Double Hydroxides (LDH): applications of interest to metallurgy
    Richetta, M.
    Varone, A.
    Pizzoferrato, R.
    METALLURGIA ITALIANA, 2019, 111 (02): : 5 - 14
  • [8] Mg-Al and Zn-Fe layered double hydroxides used for organic species storage and controlled release
    Seftel, E. M.
    Cool, P.
    Lutic, D.
    MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2013, 33 (08): : 5071 - 5078
  • [9] INTERCALATION OF ORGANIC AND INORGANIC ANIONS INTO LAYERED DOUBLE HYDROXIDES
    CHIBWE, K
    JONES, W
    JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS, 1989, (14) : 926 - 927
  • [10] Staging of organic and inorganic anions in layered double hydroxides
    Pisson, J
    Taviot-Guého, C
    Israëli, Y
    Leroux, F
    Munsch, P
    Itié, JP
    Briois, V
    Morel-Desrosiers, N
    Besse, JP
    JOURNAL OF PHYSICAL CHEMISTRY B, 2003, 107 (35): : 9243 - 9248
12345