Novel small-molecule therapy of Hodgkin lymphoma

被引：8
|
作者：
Buglio, D. [1 ]
Georgakis, G. [1 ]
Younes, A. [1 ]
机构：
[1] Univ Texas, MD Anderson Canc Ctr, Dept Lymphoma Myeloma, Houston, TX 77030 USA
来源：
EXPERT REVIEW OF ANTICANCER THERAPY | 2007年 / 7卷 / 05期
关键词：
Bcl-2; bortezomib; HDAC; HSP90; mTOR; Reed-Sternberg;
D O I：
10.1586/14737140.7.5.735
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The treatment of Hodgkin lymphoma continues to be based on combination chemotherapy and radiation therapy. Although this treatment strategy produces a high cure rate, short- and long-term toxic effects continue to be problematic for young cured patients. In this review we focus on emerging novel therapies using small molecules that target specific survival pathways in the cancer cells. This approach is aimed at improving the cure rate while reducing treatment-related toxicity.
引用
收藏
页码：735 / 740
页数：6
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