The role of the CD44/ezrin complex in cancer metastasis

被引：199
|
作者：
Martin, TA [1 ]
Harrison, G [1 ]
Mansel, RE [1 ]
Jiang, WG [1 ]
机构：
[1] Cardiff Univ, Coll Med, Dept Surg, Metastasis Res Grp, Cardiff CF14 4XN, S Glam, Wales
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2003年 / 46卷 / 02期
关键词：
CD44; ezrin; hyaluranon; cell adhesion; cancer metastasis;
D O I：
10.1016/S1040-8428(02)00172-5
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
CD44 is a cell adhesion molecule that was traditionally known as 'homing receptor'. This molecule is known to interact with the ezrin family (ERM family) members and form a complex that plays diverse roles within both normal and abnormal cells, particularly cancer cells. CD44 and ezrin and their respective complex have properties suggesting that they may be important in the process of tumour-endothelium interactions, cell migrations, cell adhesion, tumour progression and metastasis. This article reviews the role of CD44, ezrin family and the CD44/ezrin complex in cancer cells and their clinical impact in patients with cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：165 / 186
页数：22
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