Comprehensive and innovative techniques for liver transplantation in rats: A surgical guide

被引：42

作者：

Hori, Tomohide ^{[1
,2
]}

Nguyen, Justin H. ^{[3
]}

Zhao, Xiangdong ^{[4
]}

Ogura, Yasuhiro ^{[2
]}

Hata, Toshiyuki ^{[2
]}

Yagi, Shintaro ^{[5
]}

Chen, Feng ^{[1
]}

Baine, Ann-Marie T. ^{[1
]}

Ohashi, Norifumi ^{[1
]}

Eckman, Christopher B. ^{[1
]}

Herdt, Aimee R. ^{[1
]}

Egawa, Hiroto ^{[2
]}

Takada, Yasutsugu ^{[2
]}

Oike, Fumitaka ^{[2
]}

Sakamoto, Seisuke ^{[2
]}

Kasahara, Mureo ^{[2
]}

Ogawa, Kohei ^{[2
]}

Hata, Koichiro ^{[2
]}

Iida, Taku ^{[2
]}

Yonekawa, Yukihide ^{[2
]}

Sibulesky, Lena ^{[3
]}

Kuribayashi, Kagemasa ^{[6
]}

Kato, Takuma ^{[6
]}

Saito, Kanako ^{[6
]}

Wang, Linan ^{[6
]}

Torii, Mie ^{[6
]}

Sahara, Naruhiko ^{[1
]}

Kamo, Naoko ^{[2
]}

Sahara, Tomoko ^{[1
]}

Yasutomi, Motohiko ^{[7
]}

Uemoto, Shinji ^{[2
]}

机构：

[1] Mayo Clin, Dept Neurosci, Jacksonville, FL 32224 USA

[2] Kyoto Univ Hosp, Dept Surg, Div Hepatopancreatobiliary Transplant & Pediat Su, Sakyo Ku, Kyoto 6068507, Japan

[3] Mayo Clin, Dept Transplantat, Div Transplant Surg, Jacksonville, FL 32224 USA

[4] Kyoto Univ, Grad Sch Med, Transplant Tolerance Unit, Innovat Ctr Immunoregulat Technol & Drugs,Sakyo K, Kyoto 6068507, Japan

[5] Rhein Westfal TH Aachen, Inst Lab Anim Sci & Expt Surg, D-52074 Aachen, Germany

[6] Mie Univ, Grad Sch Med, Dept Cellular & Mol Immunol, Tsu, Mie 5148507, Japan

[7] Auckland City Hosp, New Zealand Liver Transplant Unit, Auckland 92024, New Zealand

来源：

WORLD JOURNAL OF GASTROENTEROLOGY | 2010年 / 16卷 / 25期

基金：

日本学术振兴会;

关键词：

Animal model; Liver transplantation; Microsurgery; Rat; Reperfusion injury; Ultra-microsurgery; MICROSURGICAL TECHNIQUES; REPERFUSION INJURY; PORTAL-VEIN; MOUSE MODEL; HEPATECTOMY; GRAFT; CUFF; MICE; ARTERIALIZATION; RECONSTRUCTION;

D O I：

10.3748/wjg.v16.i25.3120

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

AIM: To investigate our learning curves of orthotopic liver transplantation (OLT) in rats and the most important factor for successful surgery. METHODS: We describe the surgical procedures for our rat OLT model, and determined the operator learning curves. The various factors that contributed to successful surgery were determined. The most important surgical factors were evaluated between successful and unsuccessful surgeries. RESULTS: Learning curve data indicated that 50 cases were required for operator training to start a study. Operative time, blood loss, warm ischemic time, anhepatic phase, unstable systemic hemodynannic state, and body temperature after surgery significantly affected surgery success by univariate analysis, while the anhepatic phase was the most critical factor for success by multivariate analysis. CONCLUSION: OLT in rats is the only liver transplantation model that provides clinically relevant and reliable results. Shortened anhepatic phase is key to success in this model. (C) 2010 Baishideng. All rights reserved.

引用

页码：3120 / 3132

页数：13

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