Synthesis of some novel fluorinated pyrazolo[3,4-b]pyridines

被引：26
|
作者：
Singh, SP
Naithani, R [1 ]
Aggarwal, R
Prakash, O
机构：
[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA
[2] Kurukshetra Univ, Dept Chem, Kurukshetra 132119, Haryana, India
来源：
SYNTHETIC COMMUNICATIONS | 2004年 / 34卷 / 23期
关键词：
alpha-cyanoacetophones; fluorinated-beta-diketones; pyrazolo[3,4-b]pyrimidines;
D O I：
10.1081/SCC-200039427
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Reaction of 5-amino-3-substituted pyrazoles (1a-c) and 5-amino-1,3-disubstituted pyrazoles (1d-i) with fluorinated-beta-diketones (2) results in the formation of the single isomer of pyrazolo[3,4-b]pyridines (4a-h). A one-pot procedure for the synthesis of title compounds starting from alpha-cyanoacetophenones along with a possible mechanistic pathway for the formation of the title compounds is described.
引用
收藏
页码：4359 / 4367
页数：9
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