Adult neurogenesis is unaffected by a functional knock-out of MHC class I in mice

被引：8
|
作者：
Goya, Rocio Laguna [1 ]
Tyers, Pam [1 ]
Barker, Roger A. [1 ,2 ,3 ]
机构：
[1] Cambridge Ctr Brain Repair, Cambridge, England
[2] Addenbrookes Hosp, Dept Neurol, Cambridge, England
[3] Edith Cowan Univ, Perth, WA, Australia
来源：
NEUROREPORT | 2010年 / 21卷 / 05期
基金：
英国医学研究理事会;
关键词：
adult neurogenesis; major histocompatibility complex class I; TAP1 knockout mouse; water maze; HIPPOCAMPAL NEUROGENESIS; DENTATE GYRUS; CELLS; PLASTICITY; MOLECULES; NEURONS; MEMORY; CNS;
D O I：
10.1097/WNR.0b013e3283377463
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The major histocompatibility complex (MHC) class I has a role in the regulation of immune responses and has been implicated recently in neural plasticity and neurogenesis. We therefore sought to investigate in functional MHC class I knockout mice, transporter associated with antigen processing 1 (TAP1) KO, whether there are alterations in adult neurogenesis. We found no significant differences in cell proliferation or neurogenesis in either the dentate gyrus or subventricular zone, in TAP1 KO versus wild-type mice at several different time points. Our results do not support a role for MHC class I in adult neurogenesis, although it may still have a role in the maturation and integration of newborn neurons. NeuroReport 21:349-353 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
引用
收藏
页码：349 / 353
页数：5
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