Mechanisms of Resistance to Cancer Chemotherapy

被引：0

作者：

Stefanko, Ewa ^{[1
]}

Wrobel, Tomasz ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept Hematol Blood Neoplasms & Bone Marrow Transp, PL-50367 Wroclaw, Poland

来源：

ADVANCES IN CLINICAL AND EXPERIMENTAL MEDICINE | 2010年 / 19卷 / 01期

关键词：

resistance to chemotherapy; cancer cells; leukemia; lymphomas; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; DNA MISMATCH REPAIR; PROGNOSTIC-SIGNIFICANCE; CELL LYMPHOMAS; EXPRESSION; CISPLATIN; GENE; MDR1; SURVIVIN;

D O I：

暂无

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Resistance to chemotherapy is one of the major causes of failure of anticancer treatment. It can occur at every level of the drug action and includes mechanisms such as increased drug efflux and decreased influx, drug inactivation, alterations in the drug target, DNA damage repair, and evasion of apoptosis. In this article some mechanisms of drug resistance in cancer chemotherapy are reviewed (Adv Clin Exp Med 2010, 19, 1, 5-12).

引用

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页码：5 / 12

页数：8

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