NMR studies on chiral intermediates in the total synthesis of (+)-biotin from D-mannose

被引：0
|
作者：
Chen, Wen-xue [1 ]
Zhang, Ping
Chen, Fen-er [1 ]
机构：
[1] Fudan Univ, Dept Chem, Fudan DSM Joint Lab, Shanghai 200433, Peoples R China
来源：
MAGNETIC RESONANCE IN CHEMISTRY | 2010年 / 48卷 / 08期
关键词：
NMR; H-1; C-13; 1D NOE; (+)-biotin; D-mannose; D-GLUCOSE; (&)-BIOTIN; BIOTIN;
D O I：
10.1002/mrc.2619
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The chemical structure and stereochemistry of 12 intermediates in the total synthesis of (+)-biotin starting from D-mannose as chiral pool were completely assigned using one- and two-dimensional NMR experiments, including D-1 selective NOE, DEPT, COSY, HSQC and HMBC. Copyright (C) 2010 John Wiley & Sons, Ltd.
引用
收藏
页码：651 / 655
页数：5
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