Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

被引：4
|
作者：
Magnin, Geraldine [1 ,3 ]
Bissel, Philippe [1 ,3 ]
Council-Troche, Roberto Mcalister [1 ]
Zhou, Zhiguo [2 ,4 ]
Ehrich, Marion [1 ]
机构：
[1] Virginia Tech, Virginia Maryland Coll Vet Med, Blacksburg, VA 24061 USA
[2] Luna Nanoworks, Danville, VA 24541 USA
[3] Kansas State Univ, Coll Vet Med, Manhattan, KS 66502 USA
[4] Zymeron Corp, Durham, NC 27709 USA
来源：
ACS OMEGA | 2019年 / 4卷 / 20期
关键词：
ACETYLCHOLINESTERASE INHIBITION; BETA-CYCLODEXTRIN; BINDING; AGENT;
D O I：
10.1021/acsomega.9b02587
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M-1 indicates that this binding was not covalent.
引用
收藏
页码：18663 / 18667
页数：5
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