Studies Exploring the Interaction of the Organophosphorus Compound Paraoxon with Fullerenes

被引：4
|
作者：
Magnin, Geraldine [1 ,3 ]
Bissel, Philippe [1 ,3 ]
Council-Troche, Roberto Mcalister [1 ]
Zhou, Zhiguo [2 ,4 ]
Ehrich, Marion [1 ]
机构：
[1] Virginia Tech, Virginia Maryland Coll Vet Med, Blacksburg, VA 24061 USA
[2] Luna Nanoworks, Danville, VA 24541 USA
[3] Kansas State Univ, Coll Vet Med, Manhattan, KS 66502 USA
[4] Zymeron Corp, Durham, NC 27709 USA
来源：
ACS OMEGA | 2019年 / 4卷 / 20期
关键词：
ACETYLCHOLINESTERASE INHIBITION; BETA-CYCLODEXTRIN; BINDING; AGENT;
D O I：
10.1021/acsomega.9b02587
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In vitro experiments previously published demonstrated the ability of fullerenes to decrease the capability of organophosphorus (OP) compounds to inhibit acetylcholinesterase. Experiments described herein demonstrate molecular level affinity interactions between fullerenes and the OP test compound paraoxon with NMR spectroscopy. The calculated binding constant of 19 M-1 indicates that this binding was not covalent.
引用
收藏
页码：18663 / 18667
页数：5
相关论文
共 50 条
  • [1] Organophosphorus hydrolase at the air-water interface: Secondary structure and interaction with paraoxon
    Zheng, Jiayin
    Desbat, Bernard
    Rastogi, Vipin K.
    Shah, Saumil S.
    DeFrank, Joseph J.
    Leblanc, Roger M.
    BIOMACROMOLECULES, 2006, 7 (10) : 2806 - 2810
  • [2] ANTIBODIES TO ORGANOPHOSPHORUS HAPTENS - IMMUNITY TO PARAOXON POISONING
    STERNBERGER, LA
    CUCULIS, JJ
    MEYER, HG
    LENZ, DE
    KAVANAGH, WG
    FEDERATION PROCEEDINGS, 1974, 33 (03) : 728 - 728
  • [3] Binding studies for the interaction between hazardous organophosphorus compound phosmet and lysozyme: Spectroscopic and In-silico analyses
    Kaur, Lajpreet
    Rahman, Afreen J.
    Singh, Anju
    Pathak, Mallika
    Datta, Anupama
    Singhal, Rahul
    Ojha, Himanshu
    JOURNAL OF MOLECULAR LIQUIDS, 2022, 355
  • [4] Enhancing Paraoxon Binding to Organophosphorus Hydrolase Active Site
    El Khoury, Lea
    Mobley, David L.
    Ye, Dongmei
    Rempe, Susan B.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (23)
  • [5] Prevention of tolerance to the organophosphorus anticholinesterase paraoxon with carboxylesterase inhibitors
    Yang, ZP
    Dettbarn, WD
    BIOCHEMICAL PHARMACOLOGY, 1998, 55 (09) : 1419 - 1426
  • [6] INTERACTION OF A BISQUATERNARY AMMONIUM COMPOUND WITH THE PERIPHERAL ORGANOPHOSPHORUS (POP) SITE ON ACETYLCHOLINESTERASE
    FRIBOULET, A
    GOUDOU, D
    RIEGER, F
    NEUROCHEMISTRY INTERNATIONAL, 1986, 9 (02) : 323 - 328
  • [7] Inhibition with spontaneous reactivation of esterases by organophosphorus compounds:: Paraoxon as a model
    Estevez, Jorge
    Garcia, Adolfo
    Barril, Jose
    Vilanova, Eugenio
    TOXICOLOGY LETTERS, 2008, 180 : S91 - S91
  • [8] Conformational Variability of Organophosphorus Hydrolase upon Soman and Paraoxon Binding
    Gomes, Diego E. B.
    Lins, Roberto D.
    Pascutti, Pedro G.
    Lei, Chenghong
    Soares, Thereza A.
    JOURNAL OF PHYSICAL CHEMISTRY B, 2011, 115 (51): : 15389 - 15398
  • [9] Organophosphorus pesticide (Paraoxon) analysis using solid state sensors
    Dipartimento di Chimica, Università 'La Sapienza', P. le Aldo Moro 5, 00185 Rome, Italy
    Sens Actuators, B Chem, 1-3 (25-33):
  • [10] Organophosphorus pesticide (Paraoxon) analysis using solid state sensors
    Campanella, L
    Colapicchioni, C
    Favero, G
    Sammartino, MP
    Tomassetti, M
    SENSORS AND ACTUATORS B-CHEMICAL, 1996, 33 (1-3) : 25 - 33
12345