Association between the promoter haplotype of RTN4 gene and schizophrenia in a Korean population

被引：2
|
作者：
Park, Hae Jeong [1 ]
Kang, Won Sub [2 ]
Kim, Jong Woo [2 ]
机构：
[1] Kyung Hee Univ, Sch Med, Dept Pharmacol, Seoul 02447, South Korea
[2] Kyung Hee Univ, Sch Med, Dept Neuropsychiat, Seoul 02447, South Korea
来源：
PSYCHIATRY RESEARCH | 2021年 / 299卷
关键词：
Schizophrenia; RTN4; haplotype; NOGO-A; POLYMORPHISMS;
D O I：
10.1016/j.psychres.2021.113841
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Previous studies have suggested the involvement of Nogo-A/RTN4 in the pathogenesis of schizophrenia. We investigated an association between the promoter haplotypes of RTN4 comprised of rs1348528-rs1822618rs2241958 and schizophrenia. A significant association between the rare TGA haplotype and schizophrenia was shown (p < 0.0001). Additionally, the promoter activity was profoundly decreased by the TGA haplotype. These results suggested that the TGA haplotype of RTN4 may contribute to the susceptibility of schizophrenia.
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页数：3
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