TGFβ-related pathways -: role of Caenorhabditis elegans development

被引：210
|
作者：
Patterson, GI
Padgett, RW
机构：
[1] Rutgers State Univ, Dept Biochem & Mol Biol, Piscataway, NJ 08854 USA
[2] Rutgers State Univ, Waksman Inst, Piscataway, NJ 08854 USA
来源：
TRENDS IN GENETICS | 2000年 / 16卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0168-9525(99)01916-2
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Genetic and molecular analysis in Caenorhabditis elegans has produced new insights into how TGF beta-related pathways transduce signals and the developmental processes in which they function. These pathways are essential regulators of dauer formation, body-size determination, male copulatory structures and axonal guidance. Here, we review the insights that have come from standard molecular genetic experiments and discuss how the recently completed genome sequence has contributed to our understanding of these pathways.
引用
收藏
页码：27 / 33
页数：7
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