Biotherapies in large vessel vasculitis

被引：50

作者：

Ferfar, Y. ^{[1
]}

Mirault, T. ^{[2
]}

Desbois, A. C. ^{[1
]}

Comarmond, C. ^{[1
]}

Messas, E. ^{[2
]}

Savey, L. ^{[1
]}

Domont, F. ^{[1
]}

Cacoub, P. ^{[1
]}

Saadoun, D. ^{[1
]}

机构：

[1] Univ Paris 06, Grp Hosp Pitie Salpetriere, AP HP,Serv Med Interne & Immunol Clin,DHU I2B, Ctr Reference Malad Autoimmunes & Syst Rares,Immu, Paris, France

[2] Grp Hosp HEGP, AP HP, Serv Med Vasc, Ctr Natl Reference Malad Vasc Rares, Paris, France

来源：

AUTOIMMUNITY REVIEWS | 2016年 / 15卷 / 06期

关键词：

Giant cell arteritis; Takayasu; Behcet's disease; Relapsing polychondritis; Biotherapy; GIANT-CELL ARTERITIS; REFRACTORY TAKAYASU ARTERITIS; PLACEBO-CONTROLLED TRIAL; NECROSIS FACTOR THERAPY; ANTI-TNF-ALPHA; RELAPSING POLYCHONDRITIS; BEHCETS-DISEASE; POLYMYALGIA-RHEUMATICA; EULAR RECOMMENDATIONS; SUSTAINED RESPONSE;

D O I：

10.1016/j.autrev.2016.02.012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Giant cell arteritis (GCA) and Takayasu's arteritis (TA) are large vessel vasculitis (LW) and aortic involvement is not uncommon in Behcet's disease (BD) and relapsing polychondritis (RP). Glucocorticosteroids are the mainstay of therapy in LW. However, a significant proportion of patients have glucocorticoid dependance, serious side effects or refractory disease to steroids and other immunosuppressive treatments such as cyclophosphamide, azathioprine, mycophenolate mofetil and methotrexate. Recent advances in the understanding of the pathogenesis have resulted in the use of biological agents in patients with LW. Anti-tumor necrosis factor-alpha drugs seem effective in patients with refractory Takayasu arteritis and vascular BD but have failed to do so in giant cell arteritis. Preliminary reports on the use of the anti-IL6-receptor antibody (tocilizumab), in LW have been encouraging. The development of new biologic targeted therapies will probably open a promising future for patients with LW. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：544 / 551

页数：8

共 50 条

[21] Large-vessel vasculitis
不详
Nature Reviews Disease Primers, 7 (1) : 94
[22] Large-vessel vasculitis
Pugh, Dan
Karabayas, Maira
Basu, Neil
Cid, Maria C.
Goel, Ruchika
Goodyear, Carl S.
Grayson, Peter C.
McAdoo, Stephen P.
Mason, Justin C.
Owen, Catherine
Weyand, Cornelia M.
Youngstein, Taryn
Dhaun, Neeraj
NATURE REVIEWS DISEASE PRIMERS, 2022, 7 (01)
[23] Tocilizumab for Large Vessel Vasculitis
不详
ZEITSCHRIFT FUR RHEUMATOLOGIE, 2013, 72 (09): : 844 - 844
[24] Medium and large vessel vasculitis
Clivati Brandt, Hebert Roberto
Arnone, Marcelo
Sakai Valente, Neusa Yuriko
Sotto, Mirian Nacagami
Criado, Paulo Ricardo
ANAIS BRASILEIROS DE DERMATOLOGIA, 2009, 84 (01) : 55 - 67
[25] Large-vessel vasculitis
Dan Pugh
Maira Karabayas
Neil Basu
Maria C. Cid
Ruchika Goel
Carl S. Goodyear
Peter C. Grayson
Stephen P. McAdoo
Justin C. Mason
Catherine Owen
Cornelia M. Weyand
Taryn Youngstein
Neeraj Dhaun
Nature Reviews Disease Primers, 7
[26] Biotherapies to treat necrotizing vasculitis
Guillevin, L.
REVUE DE MEDECINE INTERNE, 2010, 31 : S304 - S306
[27] News on the treatment of large vessel vasculitis
Venhoff, Nils
Zeisbrich, Markus
ZEITSCHRIFT FUR RHEUMATOLOGIE, 2024, 83 (10): : 812 - 821
[28] Radioisotopic imaging in large vessel vasculitis
Huglo, D.
Lambert, M.
Raynaud, F.
Hachulla, E.
Petyt, G.
Hatron, P. -Y.
Prangere, T.
Steinling, M.
MEDECINE NUCLEAIRE-IMAGERIE FONCTIONNELLE ET METABOLIQUE, 2009, 33 (08): : 499 - 504
[29] Imaging diagnostics of large vessel vasculitis
Czihal, M.
Foerster, S.
Hoffmann, U.
RADIOLOGE, 2010, 50 (10): : 855 - 860
[30] THE INCIDENCE OF LARGE VESSEL VASCULITIS IN NORFOLK
Mukhtyar, Chetan B.
Beadsmoore, Clare
Coath, Fiona
Ducker, Georgina
Sisson, Katherine
Watts, Richard A.
RHEUMATOLOGY, 2023, 62

← 1 2 3 4 5 →