Photonic Methods to Enhance Fluorescence Correlation Spectroscopy and Single Molecule Fluorescence Detection

被引：39
|
作者：
Wenger, Jerome [1 ]
Rigneault, Herve [1 ]
机构：
[1] Aix Marseille Univ, Inst Fresnel, CNRS, Ecole Cent Marseille, F-13397 Marseille 20, France
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2010年 / 11卷 / 01期
关键词：
single molecule; fluorescence correlation spectroscopy FCS; nanophotonics; biophotonics; MODE WAVE-GUIDES; TOTAL INTERNAL-REFLECTION; SOLID IMMERSION LENS; DIELECTRIC MICROSPHERES; NANOMETRIC APERTURES; FIELD CONFINEMENT; FLUIDIC CHANNELS; MICROSCOPE; DIFFUSION; EXCITATION;
D O I：
10.3390/ijms11010206
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Recent advances in nanophotonics open the way for promising applications towards efficient single molecule fluorescence analysis. In this review, we discuss how photonic methods bring innovative solutions for two essential questions: how to detect a single molecule in a highly concentrated solution, and how to enhance the faint optical signal emitted per molecule? The focus is set primarily on the widely used technique of fluorescence correlation spectroscopy (FCS), yet the discussion can be extended to other single molecule detection methods.
引用
收藏
页码：206 / 221
页数：16
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