Establishing Absolute Lymphocyte Count Thresholds for Further Review of Peripheral Blood Lymphocytosis to Judiciously Screen for Monoclonal B-Cell Populations in Older Adults

被引：0

作者：

Muscara, Matthew J. ^{[1
]}

Cook, Benjamin A. ^{[1
]}

Dhesi, Mary S. ^{[1
]}

Groo, Stephen C. ^{[1
]}

Andrews, Jared M. ^{[1
]}

机构：

[1] Madigan Army Med Ctr, Tacoma, WA 98431 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2019年 / 152卷 / 04期

关键词：

Lymphocytosis; Absolute lymphocyte count; Threshold; Flow cytometry; Monoclonal B cell; Lymphoproliferative disorder;

D O I：

10.1093/AJCP/AQZ057

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: Lymphocytosis may represent either a lymphoproliferative disorder (LPD) or a reactive process. The absolute lymphocyte count (ALC) threshold for further evaluation of lymphocytosis is not well established. Methods: We prospectively performed flow cytometry on blood samples from patients 50 years or older with ALCs of 4.0 x 10(9) cells/L or greater without a history of an LPD. Results: Monoclonal B-cell populations were found in 34 (19.1%) of 178 cases, with incidence increasing with age. In patients younger than 75 years, no monoclonal B-cell population was identified in patients with ALCs less than 4.4 x 10(9) cells/L, while such clones were found below and above this threshold in patients 75 years and older. Conclusions: These findings support a threshold for smear review and flow cytometry no lower than 4.4 x 10(9) cells/L in patients younger than 75 years and a threshold as low as 4.0 x 10(9) cells/L in patients 75 years and older.

引用

页码：458 / 462

页数：5