Macrophage Activation in HIV-2-Infected Patients Is Less Affected by Antiretroviral Treatment-sCD163 in HIV-1, HIV-2, and HIV-1/2 Dually Infected Patients

被引：8
|
作者：
Honge, Bo L. [1 ,2 ,3 ]
Andersen, Morten N. [4 ,5 ]
Jespersen, Sanne [2 ,3 ]
Medina, Candida [6 ]
Correira, Faustino G. [6 ]
Jakobsen, Martin R. [5 ]
Laursen, Alex [3 ]
Erikstrup, Christian [1 ]
Moller, Holger J. [4 ]
Wejse, Christian [2 ,3 ,7 ]
机构：
[1] Aarhus Univ Hosp, Dept Clin Immunol, Palle Juul Jensens Blvd 99, DK-8200 Aarhus N, Denmark
[2] Indepth Network, Bandim Hlth Project, Bissau, Guinea Bissau
[3] Aarhus Univ Hosp, Dept Infect Dis, DK-8000 Aarhus, Denmark
[4] Aarhus Univ Hosp, Dept Clin Biochem, DK-8000 Aarhus, Denmark
[5] Aarhus Univ, Dept Biomed, Aarhus, Denmark
[6] Minist Hlth, Natl HIV Programme, Bissau, Guinea Bissau
[7] Aarhus Univ, Sch Publ Hlth, Ctr Global Hlth, GloHAU, Aarhus, Denmark
来源：
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES | 2016年 / 72卷 / 03期
基金：
美国国家卫生研究院;
关键词：
HIV; HIV-1; HIV-2; AIDS; CRP; sCD163; Guinea-Bissau; Africa; GUINEA-BISSAU; CD163;
D O I：
10.1097/QAI.0000000000000939
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The course of disease among HIV-2, HIV-1, and HIV-1/2 dually infected patients is different. We investigated the macrophage activation marker soluble CD163 (sCD163) dynamics in 212 HIV-1, HIV-2, and HIV-1/2 dually infected patients. There were no differences in sCD163 levels at baseline or during follow-up without antiretroviral therapy (ART). At follow-up on ART, median sCD163 levels were decreased for HIV-1-infected patients (P < 0.001), but not among HIV-2 (P = 0.093) or HIV-1/2 dually infected patients (P = 0.145). The larger decrease in sCD163 levels among HIV-1-infected patients during ART may indicate an HIV type-dependent differential effect of ART on macrophage activation during HIV infection.
引用
收藏
页码：254 / 258
页数：5
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