HIV-1/HIV-2 SERONEGATIVITY IN HIV-1 SUBTYPE-O INFECTED PATIENTS

被引：208
|
作者：
LOUSSERTAJAKA, I
BRUNVEZINET, F
SIMON, F
LY, TD
CHAIX, ML
SARAGOSTI, S
COUROUCE, AM
INGRAND, D
机构：
[1] BICHAT CLAUDE BERNARD HOSP,DEPT VIROL,VIROL LAB,F-75877 PARIS 18,FRANCE
[2] ALFRED FOURNIER INST,PARIS,FRANCE
[3] COCHIN HOSP,INSERM,U363,ICGM,PARIS,FRANCE
[4] NATL BLOOD TRANSFUS INST,PARIS,FRANCE
[5] ROBERT DEBRE HOSP,DEPT MICROBIOL,REIMS,FRANCE
来源：
LANCET | 1994年 / 343卷 / 8910期
关键词：
D O I：
10.1016/S0140-6736(94)92524-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Nine patients with atypical HIV-1 western blot profiles were diagnosed as having HIV-1 subtype O infection. All the patients were living in France; eight originated from Cameroon and one from France. Lymphocyte DNA amplification by the polymerase chain reaction was only positive when HIV-1 subtype O specific primers were used. Preliminary sequence analysis of amplified products and serological reactivity against a specific subtype O synthetic env peptide confirmed HIV-1 subtype O infection. HIV-1/HIV-2 enzyme-linked immunosorbent assays, especially those based on env peptides or on the sandwich format, can be negative in HIV-1 subtype O infection.
引用
收藏
页码：1393 / 1394
页数：2
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