A total synthesis of a new class of biazine thioglycosides

被引：24
|
作者：
Elgemeie, GH
Hussein, MM
Al-Khursani, SA
机构：
[1] Helwan Univ, Fac Sci, Dept Chem, Cairo, Egypt
[2] Cairo Univ, Fac Sci, Dept Chem, Giza, Egypt
[3] Girls Coll Sci, Dept Chem, Dammam, Saudi Arabia
来源：
JOURNAL OF CARBOHYDRATE CHEMISTRY | 2004年 / 23卷 / 8-9期
关键词：
bipyridinyl thioglycosides; biazine thioglycosides; antimetabolites;
D O I：
10.1081/CAR-200045262
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A new method for the synthesis of bipyridinyl S-glycosides 11 and 12 has provided the title compounds in a higher yield. Application of a one-pot glycosylation methodology resulted in an efficient, high-yield synthesis of biazine S-glycosides 17-20 An X-ray diffraction analysis of 11 disclosed the conformation of this glycoside as the S-glycoside and not the corresponding N-form.
引用
收藏
页码：465 / 481
页数：17
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