Increased Flexibility of Local Conformation in the N-Terminal Domain of MdmX Enhances Ligand-Binding Affinity

被引:0
|
作者
Qin, Lingyun [1 ]
Chen, Rong [1 ]
Liu, Huili [2 ]
Su, Zhengding [1 ]
机构
[1] Hubei Univ Technol, Wuhan, Peoples R China
[2] Chinese Acad Sci, Wuhan Inst Phys & Math, State Key Lab MRAMP, Natl Ctr Magnet Resonance, Wuhan, Peoples R China
关键词
D O I
10.1016/j.bpj.2015.11.2909
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
2681-Pos
引用
收藏
页码:543A / 544A
页数:7
相关论文
共 50 条
  • [41] A de novo nonsense mutation in the N-terminal of ligand-binding domain of NR2F1 gene provoked a milder phenotype of BBSOAS
    Zou, Wenjun
    Cheng, Libo
    Lu, Shui
    Wu, Zhifeng
    OPHTHALMIC GENETICS, 2020, 41 (01) : 88 - 89
  • [42] Oxidation state of the XRCC1 N-terminal domain regulates DNA polymerase β binding affinity
    Cuneo, Matthew J.
    London, Robert E.
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (15) : 6805 - 6810
  • [43] Chemistry and conformation of the ligand-binding domain of GluR2 subtype of glutamate receptors
    Cheng, Q
    Jayaraman, V
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (25) : 26346 - 26350
  • [44] The structure of the ultraspiracle ligand-binding domain reveals a nuclear receptor locked in an inactive conformation
    Clayton, GM
    Peak-Chew, SY
    Evans, RM
    Schwabe, JWR
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (04) : 1549 - 1554
  • [45] Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins
    Rizk, Shahir S.
    Paduch, Marcin
    Heithaus, John H.
    Duguid, Erica M.
    Sandstrom, Andrew
    Kossiakoff, Anthony A.
    NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 18 (04) : 437 - U69
  • [46] Allosteric control of ligand-binding affinity using engineered conformation-specific effector proteins
    Shahir S Rizk
    Marcin Paduch
    John H Heithaus
    Erica M Duguid
    Andrew Sandstrom
    Anthony A Kossiakoff
    Nature Structural & Molecular Biology, 2011, 18 : 437 - 442
  • [47] Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains
    Tikhonova I.G.
    Baskin I.I.
    Palyulin V.A.
    Zefirov N.S.
    Doklady Biochemistry and Biophysics, 2004, 397 (1-6) : 242 - 250
  • [48] Replacement of helix 1' enhances the lipid binding activity of apoE3 N-terminal domain
    Redmond, KA
    Murphy, C
    Kiss, RS
    Hauser, P
    Guigard, E
    Kay, CM
    Ryan, RO
    FASEB JOURNAL, 2006, 20 (04): : A90 - A90
  • [49] Replacement of helix 1′ enhances the lipid binding activity of apoE3 N-terminal domain
    Redmond, KA
    Murphy, C
    Narayanaswami, V
    Kiss, RS
    Hauser, P
    Guigard, E
    Kay, CM
    Ryan, RO
    FEBS JOURNAL, 2006, 273 (03) : 558 - 567
  • [50] Functional analysis of androgen receptor N-terminal and ligand binding domain interacting coregulators in prostate cancer
    Yeh, S
    Sampson, ER
    Lee, DK
    Kim, E
    Hsu, CL
    Chen, YL
    Chang, HC
    Altuwaijri, S
    Huang, KE
    Chang, C
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2000, 99 (12) : 885 - 894