Efficacy of immunosorption in patients with systemic lupus erythematosus: A double blind controlled trial

被引：0
|
作者：
Amosova, EN [1 ]
Yaremenko, OB [1 ]
Snezhkova, EA [1 ]
Drannik, GV [1 ]
机构：
[1] AA Bogomolets Natl Med Univ, Chair Hosp Therapy 1, Kiev, Ukraine
来源：
TERAPEVTICHESKII ARKHIV | 1997年 / 69卷 / 12期
关键词：
SLE; immunosorption; lupus nephritis; combined therapy; immune status;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Efficacy of immunosorption (IS) employing perfusion of whole blood through activated charcoal containing DNA was studied in 11 patients with systemic lupus erythematosus (SLE). 11 SLE patients exposed to hemosorption on charcoal free from DNA served as controls. When used in combination with intensive therapy (corticosteroids and cytostatic immunosuppressant), IS produced a positive effect on lupus nephritis symptoms in 8 out of 10 patients with kidney affection. AntiDNA antibodies blood level decreased by 53.6% after two IS procedures, while only by 36.4% after nonselective hemosorption. Reduced count and functional activity of B-cells recorded after IS contribute much to final outcome of the treatment.
引用
收藏
页码：18 / 22
页数：5
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