Ovarian sex cord-stromal tumors: an update on clinical features, molecular changes, and management

被引：45
|
作者：
Al Harbi, Rehab [1 ]
McNeish, Iain A. [2 ]
El-Bahrawy, Mona [1 ,3 ]
机构：
[1] Imperial Coll London, Dept Metab Digest & Reprod, London, England
[2] Imperial Coll London, Dept Surg & Canc, London, England
[3] Univ Alexandria, Fac Med, Dept Pathol, Alexandria, Egypt
来源：
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2021年 / 31卷 / 02期
关键词：
ovarian cancer; sex cord-gonadal stromal tumors;
D O I：
10.1136/ijgc-2020-002018
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Sex cord stromal-tumors are rare tumors of the ovary that include numerous tumor subtypes of variable histological features and biological behavior. Surgery is the main therapeutic modality for the management of these tumors, while chemotherapy and hormonal therapy may be used in some patients with progressive and recurrent tumors. Several studies investigated molecular changes in the different tumor types. Understanding molecular changes underlying the development and progression of sex cord-stromal tumors provides valuable information for diagnostic and prognostic biomarkers and potential therapeutic targets for these tumors. In this review, we provide an update on the clinical presentation, molecular changes, and management of sex cord-stromal tumors.
引用
收藏
页码：161 / 168
页数：8
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