Management of Ovarian and Testicular Sex Cord-stromal Tumors in Children and Adolescents

被引：28
|
作者：
Schultz, Kris Ann P. [1 ]
Schneider, Dominik T. [2 ]
Pashankar, Farzana [3 ]
Ross, Jonathan [4 ]
Frazier, Lindsay [5 ]
机构：
[1] Childrens Hosp & Clin Minnesota, Minneapolis, MN 55404 USA
[2] Klinikum Dortmund, Dortmund, Germany
[3] Yale Univ, New Haven, CT USA
[4] Rainbow Babies & Childrens Hosp, Univ Hosp, Cleveland, OH 44106 USA
[5] Dana Farber Canc Inst, Boston, MA 02115 USA
来源：
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2012年 / 34卷
关键词：
ovarian neoplasms; testicular neoplasms; DICER1; sex cord stromal tumors; Sertoli-Leydig; juvenile granulosa cell tumor; genetics; GRANULOSA-CELL TUMOR; BLEOMYCIN COMBINATION CHEMOTHERAPY; DICER1; MUTATIONS; PARATESTICULAR TUMORS; TESTIS TUMORS; CISPLATIN; ETOPOSIDE; MARKER; VINBLASTINE; THERAPY;
D O I：
10.1097/MPH.0b013e31824e3867
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pediatric ovarian and testicular sex cord-stromal tumors are distinct from germ cell neoplasms and may present with palpable mass or signs of hormone production. Both may be associated with specific genetic syndromes. Staging for ovarian sex cord-stromal tumors is based on the International Federation of Gynecology and Obstetrics classification for ovarian carcinoma. Treatment for those with high risk disease includes multiagent chemotherapy. Testicular stromal tumors often, though not always, follow a benign course. Additional research will help to define optimal treatment strategies for children with these rare tumors.
引用
收藏
页码：S55 / S63
页数：9
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