A new bioactive steroidal ketone from the South China Sea sponge Xestospongia testudinaria

被引：14

作者：

He, Wen-Fei ^{[1
,2
]}

Xue, Duo-Qing ^{[2
]}

Yao, Li-Gong ^{[2
]}

Li, Jia ^{[2
]}

Liu, Hai-Li ^{[2
]}

Guo, Yue-Wei ^{[2
]}

机构：

[1] Wenzhou Med Univ, Sch Pharmaceut Sci, Wenzhou 325035, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 02期

基金：

中国博士后科学基金; 欧盟第七框架计划;

关键词：

PTP1B inhibitory activity; Xestospongia testudinaria; sponge; Petrosiidae; steroidal ketone; BROMINATED POLYUNSATURATED LIPIDS; MARINE SPONGE; SOFT CORAL; SARCOPHYTON SP; INHIBITORS; ALKALOIDS; STEROLS; ACIDS;

D O I：

10.1080/10286020.2015.1056521

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new steroidal ketone (1), with an ergosta-22,25-diene side chain, was obtained from the South China Sea marine sponge Xestospongia testudinaria. The structure of 1 was determined on the basis of detailed spectroscopic analysis and by comparison with literature. Compound 1 exhibited significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B), a key target for the treatment of type II diabetes and obesity, with an IC50 value of 4.27 +/- 0.55 mu M, which is comparable with the positive control oleanolic acid (IC50=2.63 +/- 0.22 mu M).

引用

页码：195 / 199

页数：5

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