Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment

被引：4

作者：

Boyarshinova, OS

Shilova, OB

Markina, NV

Gichenok, IV

Perepelkina, OV

Poletaeva, II ^{[1
]}

机构：

[1] Moscow MV Lomonosov State Univ, Lab Physiol & Genet Behav, Dept Higher Nervous Act, Fac Biol, Moscow 117234, Russia

[2] Russian Acad Sci, NK Koltsov Inst Dev Biol, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 06期

基金：

俄罗斯基础研究基金会;

关键词：

pain sensitivity; neonatal treatment; linear mice; behavioral genetics;

D O I：

10.1023/B:BEBM.0000042703.99534.40

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes. Neonatal administration of the solvent (nociceptive stimulation) decreased pain thresholds in DBA/2, 101/HY, and RSB males, but not in female mice and animals of other strains. Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent. Injection of buspiron in the neonatal period decreased pain thresholds in RLB males.

引用

页码：532 / 534

页数：3

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