Genotype-dependent changes in pain thresholds in adult mice after neonatal treatment

被引：4
|
作者：
Boyarshinova, OS
Shilova, OB
Markina, NV
Gichenok, IV
Perepelkina, OV
Poletaeva, II [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Lab Physiol & Genet Behav, Dept Higher Nervous Act, Fac Biol, Moscow 117234, Russia
[2] Russian Acad Sci, NK Koltsov Inst Dev Biol, Moscow, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 137卷 / 06期
基金：
俄罗斯基础研究基金会;
关键词：
pain sensitivity; neonatal treatment; linear mice; behavioral genetics;
D O I：
10.1023/B:BEBM.0000042703.99534.40
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the effect of neonatal treatment with pharmacological preparations (Semax and buspiron) and solvents (distilled water and physiological saline) on the pain threshold in 3-4-month-old mice of 6 genotypes. Neonatal administration of the solvent (nociceptive stimulation) decreased pain thresholds in DBA/2, 101/HY, and RSB males, but not in female mice and animals of other strains. Neonatal administration of Semax significantly increased pain thresholds in adult DBA/2 and 101/HY males compared to those in animals neonatally treated with the solvent. Injection of buspiron in the neonatal period decreased pain thresholds in RLB males.
引用
收藏
页码：532 / 534
页数：3
相关论文
共 50 条
  • [1] Genotype-Dependent Changes in Pain Thresholds in Adult Mice after Neonatal Treatment
    O. S. Boyarshinova
    O. B. Shilova
    N. V. Markina
    I. V. Gichenok
    O. V. Perepelkina
    I. I. Poletaeva
    [J]. Bulletin of Experimental Biology and Medicine, 2004, 137 : 532 - 534
  • [2] Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats
    I. I. Poletaeva
    O. V. Perepelkina
    O. S. Boyarshinova
    I. G. Lil’p
    N. V. Markina
    T. B. Timoshenko
    A. V. Revishchin
    [J]. Russian Journal of Developmental Biology, 2012, 43 : 319 - 331
  • [3] Neonatal injections of pharmacological agents and their remote genotype-dependent effects in mice and rats
    Poletaeva, I. I.
    Perepelkina, O. V.
    Boyarshinova, O. S.
    Lil'p, I. G.
    Markina, N. V.
    Timoshenko, T. B.
    Revishchin, A. V.
    [J]. RUSSIAN JOURNAL OF DEVELOPMENTAL BIOLOGY, 2012, 43 (06) : 319 - 331
  • [4] GENOTYPE-DEPENDENT CONSUMPTION OF HYPERTONIC SALINE IN MICE
    TYLER, PA
    [J]. BEHAVIORAL BIOLOGY, 1974, 10 (01): : 113 - 117
  • [5] Unstable Maternal Environment Affects Stress Response in Adult Mice in a Genotype-Dependent Manner
    Di Segni, Matteo
    Andolina, Diego
    Luchetti, Alessandra
    Babicola, Lucy
    D'Apolito, Lina Ilaras
    Pascucci, Tiziana
    Conversi, David
    Accoto, Alessandra
    D'Amato, Francesca R.
    Ventura, Rossella
    [J]. CEREBRAL CORTEX, 2016, 26 (11) : 4370 - 4380
  • [6] Metformin treatment improves the spatial memory of aged mice in an APOE genotype-dependent manner
    Zhang, Jing
    Lin, Yingbin
    Dai, Xiaoman
    Fang, Wenting
    Wu, Xilin
    Chen, Xiaochun
    [J]. FASEB JOURNAL, 2019, 33 (06): : 7748 - 7757
  • [7] GENOTYPE-DEPENDENT MODIFICATION OF SARCOMA 37 GROWTH IN CASTRATED MICE
    WOLFF, GL
    [J]. CANCER RESEARCH, 1971, 31 (11) : 1570 - &
  • [8] THE RELATIONSHIP BETWEEN CALLOSAL VARIATION AND LATERALIZATION IN MICE IS GENOTYPE-DEPENDENT
    WARD, R
    TREMBLAY, L
    LASSONDE, M
    [J]. BRAIN RESEARCH, 1987, 424 (01) : 84 - 88
  • [9] GENOTYPE-DEPENDENT EFFECTS OF SCOPOLAMINE AND ESERINE ON EXPLORATORY BEHAVIOUR IN MICE
    VANABEEL.JH
    STRIJBOS.H
    [J]. PSYCHOPHARMACOLOGIA, 1969, 16 (02): : 81 - &
  • [10] GENOTYPE-DEPENDENT PRENATAL MODIFICATION OF MORPHOMETRIC PARAMETERS OF REPRODUCTIVE-SYSTEM OF ADULT MICE AND RATS BY GLUCOCORTICOIDS
    SHISHKINA, GT
    DYGALO, NN
    YUDIN, NS
    BORODIN, PM
    NAUMENKO, EV
    [J]. ZHURNAL OBSHCHEI BIOLOGII, 1990, 51 (03): : 412 - 418
12345