Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures

被引：0

作者：

Ha, HJ

Kwon, YS

Park, SM

Shin, T

Park, JH

Kim, HC

Kwon, MS

Wie, MB ^{[1
]}

机构：

[1] Kangweon Natl Univ, Dept Vet Med, Chunchon 200701, South Korea

[2] Cheju Natl Univ, Dept Vet Med, Cheju 690756, South Korea

[3] Kangweon Natl Univ, Dept Pharm, Neurotoxicol Program, Chunchon 200701, South Korea

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 04期

关键词：

quercetin; oxygen-glucose deprivation; N-methyl-D-aspartate; kainate; free radical; cortical culture;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 muM) inhibited 50 min OGD-, 20 muM N-methyl-D-aspartate (NMDA)-, and 50 muM kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl2, and FeCl2. These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.

引用

页码：544 / 546

页数：3

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