Quercetin attenuates oxygen-glucose deprivation- and excitotoxin-induced neurotoxicity in primary cortical cell cultures

被引：0
|
作者：
Ha, HJ
Kwon, YS
Park, SM
Shin, T
Park, JH
Kim, HC
Kwon, MS
Wie, MB [1 ]
机构：
[1] Kangweon Natl Univ, Dept Vet Med, Chunchon 200701, South Korea
[2] Cheju Natl Univ, Dept Vet Med, Cheju 690756, South Korea
[3] Kangweon Natl Univ, Dept Pharm, Neurotoxicol Program, Chunchon 200701, South Korea
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2003年 / 26卷 / 04期
关键词：
quercetin; oxygen-glucose deprivation; N-methyl-D-aspartate; kainate; free radical; cortical culture;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The possible role of quercetin, a naturally occurring plant flavonoid, in protecting against oxygen-glucose deprivation (OGD)-, excitotoxins-, and free radical-induced neuronal injury in mouse cortical cell cultures was investigated. Pre- and co-treatment with quercetin (100 muM) inhibited 50 min OGD-, 20 muM N-methyl-D-aspartate (NMDA)-, and 50 muM kainate-induced neurotoxicity by 36, 22, and 61%, respectively. Quercetin significantly ameliorated free radical-induced neuronal injury caused by buthionine sulfoximine, sodium nitroprusside, ZnCl2, and FeCl2. These results suggest that quercetin may contribute a neuroprotective action against ischemic neural injury, partially via antioxidant actions.
引用
收藏
页码：544 / 546
页数：3
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