The melanocortin system

被引：363
|
作者：
Gantz, I
Fong, TM
机构：
[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA
[2] Merck & Co Inc, Merck Sharp & Dohme Res Labs, Rahway, NJ 07065 USA
来源：
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM | 2003年 / 284卷 / 03期
关键词：
inflammation; obesity; pigmentation; sexual function; receptor;
D O I：
10.1152/ajpendo.00434.2002
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The melanocortin system consists of melanocortin peptides derived from the proopiomelanocortin gene, five melanocortin receptors, two endogenous antagonists, and two ancillary proteins. This review provides an abbreviated account of the basic biochemistry, pharmacology, and physiology of the melanocortin system and highlights progress made in four areas. In particular, recent pharmacological and genetic studies have affirmed the role of melanocortins in pigmentation, inflammation, energy homeostasis, and sexual function. Development of selective agonists and antagonists is expected to further facilitate the investigation of these complex physiological functions and provide an experimental basis for new pharmacotherapies.
引用
收藏
页码：E468 / E474
页数：7
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