The First Total Synthesis of Pectinolides D and E and Total Synthesis of Pectinolides A and C

被引：5

作者：

Sabitha, Gowravaram ^{[1
]}

AnkiReddy, Praveen ^{[1
]}

Das, Sukant Kishore ^{[1
]}

机构：

[1] Indian Inst Chem Technol, CSIR, Nat Prod Chem Div, Hyderabad 500007, Andhra Pradesh, India

来源：

SYNTHESIS-STUTTGART | 2015年 / 47卷 / 03期

关键词：

pectinolides; first synthesis; aldehyde-alkyne coupling; Noyori reduction; Still-Genari cis-olefination; STEREOSELECTIVE TOTAL-SYNTHESIS; HYPTIS-PECTINATA; D-MANNITOL; LACTONE;

D O I：

10.1055/s-0034-1378912

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of pectinolides D and E and total synthesis of pectinolides A and C was achieved from a hitherto unknown common key building block prepared from readily available D-mannitol. Key reactions involved in the synthesis are Red-Al reduction of an epoxy alcohol, enantioselective Noyori reduction of ynones, aldehyde-alkyne coupling, and Still-Genari cis-olefination.

引用

页码：330 / 342

页数：13

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