Potential of neuropeptide Y for preventing or treating post-traumatic stress disorder

被引：62

作者：

Sabban, Esther L. ^{[1
]}

Alaluf, Lishay G. ^{[1
]}

Serova, Lidia I. ^{[1
]}

机构：

[1] New York Med Coll, Dept Biochem & Mol Biol, Basic Sci Bldg, Valhalla, NY 10595 USA

来源：

NEUROPEPTIDES | 2016年 / 56卷

关键词：

Intranasal; Resilience; PTSD; Depression; Single prolonged stress; CORTICOTROPIN-RELEASING-FACTOR; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; LOCUS-CERULEUS NEURONS; MESSENGER-RNA; ARCUATE NUCLEUS; DIFFERENTIAL REGULATION; METABOLIC SYNDROME; RECEPTOR SUBTYPES; GENETIC-VARIATION; RESTRAINT STRESS;

D O I：

10.1016/j.npep.2015.11.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There is extensive evidence that NPY in the brain can modulate the responses to stress and play a critical role in resistance to, or recovery from, harmful effects of stress. Development of PTSD and comorbid depression following exposure to traumatic stress are associated with low NPY. This review discusses putative mechanisms for NPY's anti-stress actions. Recent preclinical data indicating potential for intranasal delivery of NPY to brain as a promising non-invasive strategy to prevent a variety of neuroendocrine, molecular and behavioral impairments in PTSD model are summarized. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：19 / 24

页数：6

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