Four new highly oxidized sesquiterpene lactones from the leaves of Artemisia argyi

被引：8
|
作者：
Zhao, Hua-Rong
Liu, Xiao-Qin
Wu, Xiu-Tao
Kong, Ling-Yi [1 ,2 ]
Luo, Jian-Guang [1 ,2 ]
机构：
[1] China Pharmaceut Univ, Sch Tradit Chinese Pharm, Jiangsu Key Lab Bioact Nat Prod Res, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
[2] China Pharmaceut Univ, Sch Tradit Chinese Pharm, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Peoples R China
来源：
PHYTOCHEMISTRY LETTERS | 2021年 / 43卷
关键词：
Sesquiterpene lactones; Argyoxynolides; Artemisia argyi; Nitric oxide; DERIVATIVES; CONFIGURATION; MOXA;
D O I：
10.1016/j.phytol.2021.03.011
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four new highly oxidized sesquiterpene lactones, Argyoxynolides A-D, along with two known analogs were isolated from the leaves of Artemisia argyi H.Le ' v. & Vaniot. Their structures were characterized utilizing extensive spectroscopic methods. All isolates were evaluated for the LPS-induced nitric oxide (NO) production inhibitory activity and one compound exhibited activity with IC50 = 37.95 +/- 4.39 mu M.
引用
收藏
页码：173 / 178
页数：6
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