Life course breast cancer risk factors and adult breast density (United Kingdom)?

被引:60
|
作者
Jeffreys, M
Warren, R
Gunnell, D
McCarron, P
Smith, GD
机构
[1] Massey Univ, Ctr Pul Hlth Res, Wellington, New Zealand
[2] Univ Bristol, Dept Social Med, Bristol BS8 1TH, Avon, England
[3] Addenbrookes Hosp, Dept Radiol, Cambridge CB2 2QQ, England
[4] Queens Univ Belfast, Dept Epidemiol & Publ Hlth, Belfast BT7 1NN, Antrim, North Ireland
关键词
mammography; breast neoplasms; life course epidemiology; risk factors; breast density;
D O I
10.1007/s10552-004-2473-2
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: To determine whether risk factors in childhood and early adulthood affect later mammographic breast density. Methods: Subjects were 628 women who attended a medical examination at the University of Glasgow Student Health Service (1948-1968), responded to a questionnaire (2001) and had a screening mammogram in Scotland (1989-2002). Mammograms (median age of 59 years) were classified using a six category classification (SCC) of breast density percent. Logistic regression was used to determine associations between risk factors and having a high-risk mammogram (greater than or equal to25% dense). Results: In multi-variable analyses, high-risk mammograms were associated with parity (adjusted odds ratio (OR) per child: 0.77 (95% confidence interval (CI) 0.61-0.99)), age at first birth, OR per year: 1.05 (0.99-1.11), smoking at university, OR smokers versus non-smokers: 0.58 (0.36-0.92) and body mass index (BMI) while at university, OR per 1 kg/m(2) 0.75 (0.69-0.82). No associations with SCC were found for age at menarche, birth weight, oral contraceptive (OC) use, height, leg length or exercise at age 20. Conclusions: We confirm previous findings that breast density is affected by reproductive events and some anthropometric measures, however most of the risk factors acting throughout the life course which we examined were not closely related to adult breast density.
引用
收藏
页码:947 / 955
页数:9
相关论文
共 50 条
  • [21] Risk factors for male breast cancer (United States)
    Hsing, AW
    McLaughlin, JK
    Cocco, P
    Chien, HTC
    Fraumeni, JF
    CANCER CAUSES & CONTROL, 1998, 9 (03) : 269 - 275
  • [22] Risk Factors for Male Breast Cancer (United States)
    Ann W. Hsing
    Joseph K. McLaughlin
    Pierluigi Cocco
    Harvey T. Co Chien
    Joseph F. Fraumeni
    Cancer Causes & Control, 1998, 9 : 269 - 275
  • [23] Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States)
    Erin J. Aiello
    Diana S. M. Buist
    Emily White
    Cancer Causes & Control, 2006, 17 : 1227 - 1235
  • [24] Do breast cancer risk factors modify the association between hormone therapy and mammographic breast density? (United States)
    Aiello, Erin J.
    Buist, Diana S. M.
    White, Emily
    CANCER CAUSES & CONTROL, 2006, 17 (10) : 1227 - 1235
  • [25] Evidence that adult life risk factors influence the expression of familial propensity to breast cancer
    Katsouyanni, K
    Signorello, LB
    Lagiou, P
    Egan, K
    Trichopoulos, D
    EPIDEMIOLOGY, 1997, 8 (05) : 592 - 595
  • [26] ASSOCIATION OF MAMMOGRAPHIC BREAST DENSITY WITH BREAST-CANCER RISK-FACTORS
    KUNI, CC
    VACHON, C
    KING, RA
    BARTOW, S
    KUSHI, LH
    MCGOVERN, PG
    ANDERSON, VE
    RICH, SS
    SELLERS, TA
    AMERICAN JOURNAL OF EPIDEMIOLOGY, 1995, 141 (11) : S14 - S14
  • [27] Effects of mammographic density and benign breast disease on breast cancer risk (United States)
    Byrne, C
    Schairer, C
    Brinton, LA
    Wolfe, J
    Parekh, N
    Salane, M
    Carter, C
    Hoover, R
    CANCER CAUSES & CONTROL, 2001, 12 (02) : 103 - 110
  • [28] Effects of mammographic density and benign breast disease on breast cancer risk (United States)
    Celia Byrne
    Catherine Schairer
    Louise A. Brinton
    John Wolfe
    Navin Parekh
    Martine Salane
    Christine Carter
    Robert Hoover
    Cancer Causes & Control, 2001, 12 : 103 - 110
  • [30] The experiences of men with breast cancer in the United Kingdom
    Iredale, R
    Brain, K
    Williams, B
    France, E
    Gray, J
    EUROPEAN JOURNAL OF CANCER, 2006, 42 (03) : 334 - 341