TGFβ3 is expressed in differentiating muscle of the embryonic mouse tongue

被引：2

作者：

Yamane, Akira ^{[1
]}

Fukui, Tadayoshi ^{[2
]}

Suga, Takeo ^{[3
]}

Iida, Ryohei ^{[3
]}

Morito, Mitsuhiko ^{[3
]}

机构：

[1] Tsurumi Univ, Dept Biophys, Sch Dent Med, Tsurumi Ku, Yokohama, Kanagawa 2308501, Japan

[2] Tsurumi Univ, Dept Orthodont, Sch Dent Med, Yokohama, Kanagawa 2308501, Japan

[3] Tsurumi Univ, Dept Geriatr Dent, Sch Dent Med, Yokohama, Kanagawa 2308501, Japan

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY | 2010年 / 54卷 / 01期

关键词：

TGF beta; TGF beta R; smad2/3; tongue; muscle differentiation; TRANSFORMING-GROWTH-FACTOR; FACTOR-BETA; TGF-BETA; SKELETAL-MUSCLE; STRIATED-MUSCLE; MASSETER MUSCLE; TRANSCRIPTION; CELLS; MICE; PROLIFERATION;

D O I：

10.1387/ijdb.082835ay

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The purpose of the present study was to elucidate the involvement of transforming growth factor betas (TGF beta s) in the differentiation of tongue striated muscles by analyzing the expression of TGF beta s, their receptors and factors of TGF beta signal transduction in the mouse tongue between embryonic days 11 (E11) and E15. The expression levels of TGF beta 3 mRNA and protein were much higher than those of TGF beta 1 and TGF beta 2, and the immunolocalization of TGF beta 3 was more consistent with the differentiating muscle cells in comparison with those of TGF beta 1 and 2 between E12 and E15. TGF beta RI and II were localized to the differentiating muscle cells between E11 and E15. Phosphorylated-smad2/3 was localized to the nucleus of muscle cells which just began to differentiate. These results suggest that the signal of TGF beta 3, but not that of beta 1 or beta 2, may be involved in the early stages (particularly the beginning) of differentiation of mouse tongue muscle cells through TGF beta RI, TGF beta RII, and smad2/3.

引用

页码：221 / 226

页数：6

共 50 条

[41] Progesterone Increases Dopamine Neurone Number in Differentiating Mouse Embryonic Stem Cells
Diaz, N. F.
Diaz-Martinez, N. E.
Velasco, I.
Camacho-Arroyo, I.
JOURNAL OF NEUROENDOCRINOLOGY, 2009, 21 (08) : 730 - 736
[42] Transcription factor AP-2 expressed in differentiating mouse retina cells
Strissel, KJ
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 1997, 38 (04) : 5299 - 5299
[43] An Improved Method for Differentiating Mouse Embryonic Stem Cells into Cerebellar Purkinje Neurons
Alexander, Christopher J.
Hammer, John A.
CEREBELLUM, 2019, 18 (03): : 406 - 421
[44] Effects of vitamin A and retinoic acid on mouse embryonic stem cells and their differentiating progeny
Asson-Batres, Mary Ann
Norwood, Christopher W.
RETINOID SIGNALING PATHWAYS, 2020, 637 : 341 - 365
[45] An Improved Method for Differentiating Mouse Embryonic Stem Cells into Cerebellar Purkinje Neurons
Christopher J. Alexander
John A. Hammer
The Cerebellum, 2019, 18 : 406 - 421
[46] Phenotypic Screening of Drug Library in Actively Differentiating Mouse Embryonic Stem Cells
Billard, Benedicte
Chang, Chih-Ning
Singh, Arun J.
Gross, Michael K.
Allen, Robert
Kioussi, Chrissa
JOURNAL OF BIOMOLECULAR SCREENING, 2016, 21 (04) : 399 - 407
[47] An approach for differentiating uniform glutamatergic neurons from mouse embryonic stem cells
Chuang, Jen-Hua
Tung, Li-Chu
Lee-Chen, Guey-Jen
Yin, Yi
Lin, Yenshou
ANALYTICAL BIOCHEMISTRY, 2011, 410 (01) : 149 - 151
[48] DNA-DEPENDENT DNA POLYMERASES IN DIFFERENTIATING EMBRYONIC MUSCLE-CELLS
WICHA, M
STOCKDALE, FE
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1972, 48 (05) : 1079 - +
[49] Expressions of TGF-betas and BMPs during development of mouse tongue.
Yamane, A
Nagata, J
DEVELOPMENTAL BIOLOGY, 2004, 271 (02) : 566 - 567
[50] TGFβ2 involves corneal morphogenesis during mouse embryonic development
Kao, WWY
Saika, S
Saika, S
Liu, CY
Kao, C
Sanford, LP
Azhar, M
Doetschman, T
MOLECULAR BIOLOGY OF THE CELL, 1999, 10 : 273A - 273A

← 1 2 3 4 5 →