Reconstitution of Polyketide-Derived Meroterpenoid Biosynthetic Pathway in Aspergillus oryzae

被引：20
|
作者：
Awakawa, Takayoshi [1 ,2 ]
Abe, Ikuro [1 ,2 ]
机构：
[1] Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Nat Prod Chem, Bunkyo Ku, Tokyo 1130033, Japan
[2] Univ Tokyo, Collaborat Res Inst Innovat Microbiol, Bunkyo Ku, Yayoi 1-1-1, Tokyo 1138657, Japan
来源：
JOURNAL OF FUNGI | 2021年 / 7卷 / 06期
关键词：
Aspergillus oryzae; heterologous expression; secondary metabolites; meroterpenoid; TERRETONIN BIOSYNTHESIS; TRANSFORMATION SYSTEM; GENE; IDENTIFICATION; CLONING; HOST; CONSTRUCTION; DISRUPTION; EXPRESSION; DISCOVERY;
D O I：
10.3390/jof7060486
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The heterologous gene expression system with Aspergillus oryzae as the host is an effective method to investigate fungal secondary metabolite biosynthetic pathways for reconstruction to produce un-natural molecules due to its high productivity and genetic tractability. In this review, we focus on biosynthetic studies of fungal polyketide-derived meroterpenoids, a group of bioactive natural products, by means of the A. oryzae heterologous expression system. The heterologous expression methods and the biosynthetic reactions are described in detail for future prospects to create un-natural molecules via biosynthetic re-design.
引用
收藏
页数：10
相关论文
共 50 条
  • [21] STEREOCONTROLLED SYNTHESIS OF CHIRAL SYNTHONS FOR POLYKETIDE-DERIVED NATURAL-PRODUCTS
    OIKAWA, Y
    NISHI, T
    ITAYA, H
    YONEMITSU, O
    TETRAHEDRON LETTERS, 1983, 24 (19) : 1987 - 1990
  • [22] Biosynthetic pathway of macrolactam polyketide antibiotic cremimycin
    Amagai, Keita
    Kudo, Fumitaka
    Eguchi, Tadashi
    TETRAHEDRON, 2011, 67 (44) : 8559 - 8563
  • [23] Discovery of a new bacterial polyketide biosynthetic pathway
    Moore, BS
    Hopke, JN
    CHEMBIOCHEM, 2001, 2 (01) : 35 - 38
  • [24] Biosynthetic Pathway of the Reduced Polyketide Product Citreoviridin in Aspergillus terreus var. aureus Revealed by Heterologous Expression in Aspergillus nidulans
    Lin, Tzu-Shyang
    Chiang, Yi-Ming
    Wang, Clay C. C.
    ORGANIC LETTERS, 2016, 18 (06) : 1366 - 1369
  • [25] Trial and Error in Total Synthesis of Polyketide-derived Polycyclic Natural Products
    Takikawa, Hiroshi
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2018, 76 (05) : 478 - 481
  • [26] Biosynthesis of polyketide-terpenoid (meroterpenoid) metabolites andibenin B and andilesin A in Aspergillus variecolor
    Simpson, TJ
    Ahmed, SA
    McIntyre, CR
    Scott, FE
    Sadler, IH
    TETRAHEDRON, 1997, 53 (11) : 4013 - 4034
  • [27] The iterative synthesis of acyclic deoxypropionate units and their implication in polyketide-derived natural products
    Hanessian, S
    Giroux, S
    Mascitti, V
    SYNTHESIS-STUTTGART, 2006, 7 (07): : 1057 - 1076
  • [28] Discovery of a novel superfamily of type III polyketide synthases in Aspergillus oryzae
    Seshime, Y
    Juvvadi, PR
    Fujii, I
    Kitamoto, K
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 331 (01) : 253 - 260
  • [29] Engineering Aspergillus oryzae for the Heterologous Expression of a Bacterial Modular Polyketide Synthase
    Feng, Jin
    Hauser, Maurice
    Cox, Russell J.
    Skellam, Elizabeth
    JOURNAL OF FUNGI, 2021, 7 (12)
  • [30] Aspergillus oryzae Biosynthetic Platform for de Novo Iridoid Production
    Duan, Yali
    Liu, Jiawei
    Du, Yun
    Pei, Xiaolin
    Li, Mu
    JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2021, 69 (08) : 2501 - 2511
12345