P>Burkholderia cepacia complex (Bcc) bacteria have gained notoriety as pathogens in cystic fibrosis (CF) because they are difficult to identify and treat, and also have the ability to spread between CF individuals. Of the 17 formally named species within the complex, Burkholderia multivorans and Burkholderia cenocepacia dominate in CF. Multilocus sequence typing has proven to be a very useful tool for tracing the global epidemiology of Bcc bacteria and has shown that B. cenocepacia strains with high transmissibility, such as the ET-12 strain (ST-28) and the Czech strain (ST-32), have spread epidemically within CF populations in Canada and Europe. The majority of research on the molecular pathogenesis of Bcc bacteria has focused on the B. cenocepacia ET-12 epidemic lineage, with gene mutation, genome sequence analysis and, most recently, global gene expression studies shedding considerable light on the virulence and antimicrobial resistance of this pathogen. These studies demonstrate that the ability of B. cenocepacia to acquire foreign DNA (genomic islands, insertion sequences and other mobile elements), regulate gene expression via quorum sensing, compete for iron during infection, and mediate antimicrobial resistance and inflammation via its membrane and surface polysaccharides are key features that underpin the virulence of different strains. With the wealth of molecular knowledge acquired in the last decade on B. cenocepacia strains, we are now in a much better position to develop strategies for the treatment of pathogenic colonization with Bcc and to answer key questions on pathogenesis concerning, for example, the factors that trigger the rapid clinical decline in CF patients.
机构:
Univ Western Ontario, Dept Microbiol & Immunol, Ctr Human Immunol, London, ON N6A 5C1, CanadaUniv Western Ontario, Dept Microbiol & Immunol, Ctr Human Immunol, London, ON N6A 5C1, Canada
Loutet, Slade A.
Valvano, Miguel A.
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Univ Western Ontario, Dept Microbiol & Immunol, Ctr Human Immunol, London, ON N6A 5C1, Canada
Univ Western Ontario, Dept Med, London, ON N6A 5C1, CanadaUniv Western Ontario, Dept Microbiol & Immunol, Ctr Human Immunol, London, ON N6A 5C1, Canada
机构:
Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
de Freitas Vianna, Edgard
Menezes, Nicoli Izzy Miotto
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
Menezes, Nicoli Izzy Miotto
de Almeida, Mila Muraro
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
de Almeida, Mila Muraro
de Freitas, Fla'via Alvim Dutra
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
de Freitas, Fla'via Alvim Dutra
da Costa Ferreira Leite, Cassiana
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
da Costa Ferreira Leite, Cassiana
Firmida, Monica Cassia
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Doencas Torax, Rio De Janeiro, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
Firmida, Monica Cassia
de Medeiros, Davi Ribeiro Iglesias
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
de Medeiros, Davi Ribeiro Iglesias
Souza Leao, Robson
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
Souza Leao, Robson
Mattos Albano, Rodolpho
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Univ Estado Rio De Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Bioquim, Rio De Janeiro, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
Mattos Albano, Rodolpho
Andrade Marques, Elizabeth
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Univ Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, BrazilUniv Estado Rio De Janeiro, Fac Ciencias Med, Dept Microbiol Imunol & Parasitol, Av 28 Setembro 87,3o Andar Vila Isabel, BR-20551030 Rio De Janeiro, RJ, Brazil
机构:
Harbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
Huse, Holly K.
Lee, Mark J.
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Duke Univ, Sch Med, Dept Pathol & Clin Microbiol Lab, Durham, NC USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
Lee, Mark J.
Wootton, Mandy
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机构:
Univ Hosp Wales, Specialist Antimicrobial Chemotherapy Unit, Publ Hlth Wales, Cardiff, WalesHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
Wootton, Mandy
Sharp, Susan E.
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机构:
Copan Diagnost, Murrieta, CA USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
Sharp, Susan E.
Traczewski, Maria
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机构:
Clin Microbiol Inst Inc, Wilsonville, OR USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
Traczewski, Maria
LiPuma, John J.
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Univ Michigan, Dept Pediat, Ann Arbor, MI 48109 USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA
LiPuma, John J.
Jorth, Peter
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机构:
Cedars Sinai Med Ctr, Dept Pathol & Lab Med, Med & Biomed Sci, Los Angeles, CA 90048 USAHarbor UCLA Med Ctr, Dept Pathol & Lab Med, Torrance, CA 90509 USA