Broadband Coherent anti-Stokes Raman Scattering (CARS): a potential tool for atherosclerosis diagnostic imaging

被引：0

作者：

Cormier, J. -F. ^{[1
]}

Ko, A. ^{[2
]}

Choo-Smith, L. -P. ^{[2
]}

Werner, J. ^{[2
]}

Kohlenberg, E. ^{[2
]}

Hewko, M. ^{[2
]}

Frechette, J. ^{[1
]}

Fortin, M. ^{[1
]}

Noiseux, I. ^{[1
]}

Bouchard, J. P. ^{[1
]}

Gay, D. ^{[1
]}

Desroches, P. ^{[1
]}

Roy-Moisan, F. ^{[1
]}

Bourgault, M. -E. ^{[1
]}

Sowa, M. G. ^{[2
]}

Vernon, M. L. ^{[1
]}

机构：

[1] Natl Opt Inst, 2740 Einstein, Ste Foy, PQ G1P 4S4, Canada

[2] Natl Res Council Canada, Inst Biodiagnost, Winnipeg, MB R3B 1Y6, Canada

来源：

PHOTONIC THERAPEUTICS AND DIAGNOSTICS III | 2007年 / 6424卷

关键词：

broadband CARS; coherent anti-stokes raman scattering; raman spectroscopy; atherosclerosis;

D O I：

10.1117/12.701243

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nonlinear optical imaging technologies offer some intriguing medical diagnostic applications. Examples include fast imaging of elastin and collagen distributions in diseased tissues using two-photon fluorescence (TPF) and second harmonic generation (SHG), respectively. The 3D sectioning capabilities and biochemical specificity that enable fast imaging in highly scattering biological media lie at the heart of the appeal of these nonlinear approaches for medical applications. One of these promising nonlinear techniques relies on the resonance enhancement of the third order nonlinear susceptibility by a vibrational mode of a molecule. Coherent Anti-Stokes Raman Scattering (CARS) can provide similar vibrational information as a spontaneous Raman spectrum. The technique has been shown to be orders of magnitude more sensitive than spontaneous Raman, with video rate imaging demonstrated recently. In this work, we investigate the potential use of broadband CARS spectroscopy and CARS imaging for biochemical analysis of arterial tissue. Biochemical imaging, data from broadband CARS is compared with spontaneous Raman micro spectroscopy. The broadband CARS system comprised of a single femtosecond-laser is presented in detail. Issues related to data analysis, the advantages and current limitations of the CARS technique in biodiagnostics are discussed.

引用

页数：12

共 50 条

[21] Single pulse coherent anti-Stokes Raman scattering (CARS) microscopy
Lim, SH
Caster, AG
Leone, SR
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U303 - U303
[22] Coherent anti-Stokes Raman scattering microscopy (CARS): Instrumentation and applications
Djaker, Nadia
Lenne, Pierre-Francois
Marguet, Didier
Colonna, Anne
Hadjur, Christophe
Rigneault, Herve
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 2007, 571 (1-2): : 177 - 181
[23] Single pulse interferometric coherent anti-Stokes Raman scattering (CARS)
Lim, Sang-Hyun
Caster, Allison G.
Leone, Stephen R.
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES VII, 2007, 6442
[24] Highly efficient coherent anti-Stokes Raman scattering (CARS)-microscopy
Hellerer, T
Enejder, AMK
Burkacky, O
Zumbusch, A
MULTIPHOTON MICROSCOPY IN THE BIOMEDICAL SCIENCES IV, 2004, 5323 : 223 - 229
[25] Refractive effects in coherent anti-Stokes Raman scattering (CARS) microscopy
不详
EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 2005, 34 (06): : 816 - 816
[26] Live cell CARS (Coherent Anti-Stokes Raman Scattering) microscopy
Zumbusch, A
Hellerer, T
BIOPHYSICAL JOURNAL, 2001, 80 (01) : 164A - 164A
[27] Coherent anti-Stokes Raman scattering (CARS) microscopy for biology and medicine
Xie, XS
Potma, EO
Evans, CL
Yang, WY
Lin, C
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U197 - U197
[28] Coherent anti-Stokes Raman scattering (CARS) microscopy imaging at interfaces: evidence of interference effects
Gachet, D.
Billard, F.
Sandeau, N.
Rigneault, H.
OPTICS EXPRESS, 2007, 15 (16): : 10408 - 10420
[29] Adaptation of a commercial multiphoton microscope to perform coherent anti-Stokes Raman scattering (CARS) imaging
Nowak, KL
Rector, KD
BIOPHYSICAL JOURNAL, 2004, 86 (01) : 321A - 321A
[30] Coherent anti-stokes Raman scattering (CARS) microscopy: Cellular imaging with vibrational contrast.
Potma, EO
Cheng, JX
Nan, XL
Xie, XS
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2003, 226 : U279 - U279

← 1 2 3 4 5 →