Rhodium-catalyzed asymmetric hydrogenation of unprotected β-enamine phosphonates

被引：11
|
作者：
Zhou, Ming [1 ]
Xue, Zejian [1 ]
Cao, Min [1 ]
Dong, Xiu-Qin [1 ]
Zhang, Xumu [1 ]
机构：
[1] Wuhan Univ, Coll Chem & Mol Sci, Wuhan 430072, Hubei, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2016年 / 14卷 / 20期
基金：
中国国家自然科学基金;
关键词：
ALPHA-AMINO; AMINOPHOSPHONATES; INHIBITOR;
D O I：
10.1039/c6ob00540c
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We have successfully developed a strategy for the first time for the enantioselective Rh-TaniaPhos catalyzed asymmetric hydrogenation of unprotected beta-enamine phosphonates to free beta-amino phosphonates directly with good enantioselectivities (80%-86% ee) and high conversions (>99% conversion). The resulting chiral free beta-amino phosphonates and their derivatives are important intermediates in biochemistry and pharmaceuticals.
引用
收藏
页码：4582 / 4584
页数：3
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