The Australian dingo is an early offshoot of modern breed dogs

被引：20

作者：

Field, Matt A. ^{[1
,2
]}

Yadav, Sonu ^{[3
]}

Dudchenko, Olga ^{[4
,5
]}

Esvaran, Meera ^{[6
]}

Rosen, Benjamin D. ^{[7
]}

Skvortsova, Ksenia ^{[2
]}

Edwards, Richard J. ^{[3
]}

Keilwagen, Jens ^{[8
]}

Cochran, Blake J. ^{[9
]}

Manandhar, Bikash ^{[9
]}

Bustamante, Sonia ^{[10
]}

Rasmussen, Jacob Agerbo ^{[11
,12
]}

Melvin, Richard G. ^{[13
]}

Chernoff, Barry ^{[14
,15
]}

Omer, Arina ^{[4
]}

Colaric, Zane ^{[4
]}

Chan, Eva K. F. ^{[2
,16
]}

Minoche, Andre E. ^{[2
]}

Smith, Timothy P. L. ^{[17
]}

Gilbert, M. Thomas P. ^{[11
,18
]}

Bogdanovic, Ozren ^{[2
,3
]}

Zammit, Robert A. ^{[19
]}

Thomas, Torsten ^{[6
]}

Aiden, Erez L. ^{[4
,5
,20
,21
,22
]}

Ballard, J. William O. ^{[23
,24
]}

机构：

[1] James Cook Univ, Coll Publ Hlth, Ctr Trop Bioinformat & Mol Biol, Cairns, Qld 4878, Australia

[2] Garvan Inst Med Res, Victoria St, Darlinghurst, NSW 2010, Australia

[3] UNSW Sydney, Sch Biotechnol & Biomol Sci, High St, Kensington, NSW 2052, Australia

[4] Baylor Coll Med, Ctr Genome Architecture, Houston, TX 77030 USA

[5] Rice Univ, Ctr Theoret Biol Phys, Houston, TX 77005 USA

[6] Univ New South Wales, Sch Biol Earth & Environm Sci, Sydney, NSW 2052, Australia

[7] ARS, Anim Genom & Improvement Lab, USDA, Beltsville, MD 20705 USA

[8] Julius Kuhn Inst, Erwin Baur Str 27, D-06484 Quedlinburg, Germany

[9] Univ New South Wales, Sch Med Sci, Sydney, NSW 2052, Australia

[10] Univ New South Wales, Mark Wainwright Analyt Ctr, Bioanalyt Mass Spectrometry Facil, Sydney, NSW 2052, Australia

[11] Univ Copenhagen, Dept Biol, Lab Genom & Mol Biomed, DK-2100 Copenhagen, Denmark

[12] Univ Copenhagen, Fac Hlth & Med Sci, Ctr Evolutionary Hologen, Globe Inst, Copenhagen, Denmark

[13] Univ Minnesota, Dept Biomed Sci, Med Sch, 1035 Univ Dr, Duluth, MN 55812 USA

[14] Wesleyan Univ, Coll Environm, Dept Biol, Middletown, CT 06459 USA

[15] Wesleyan Univ, Coll Environm, Dept Earth & Environm Sci, Middletown, CT 06459 USA

[16] New South Wales Hlth Pathol, Statewide Genom, 45 Watt St, Newcastle, NSW 2300, Australia

[17] Agr Res Serv, US Meat Anim Res Ctr, USDA, Rd 313, Clay Ctr, NE 68933 USA

[18] Univ Museum, NTNU, Trondheim, Norway

[19] Vineyard Vet Hosp, 703 Windsor Rd, Vineyard, NSW 2765, Australia

[20] Univ Western Australia, UWA Sch Agr & Environm, Perth, WA 6009, Australia

[21] ShanghaiTech Univ, Shanghai Inst Adv Immunochem Studies, Pudong 201210, Peoples R China

[22] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA

[23] La Trobe Univ, Dept Environm & Genet, SABE, Melbourne, Vic 3086, Australia

[24] Univ Melbourne, Sch Biosci, Royal Parade, Parkville, Vic 3052, Australia

来源：

SCIENCE ADVANCES | 2022年 / 8卷 / 16期

基金：

新加坡国家研究基金会; 英国医学研究理事会; 澳大利亚研究理事会;

关键词：

URSODEOXYCHOLIC ACID; MOLECULAR-CLONING; GENOME; DIET; DOMESTICATION; CONSEQUENCES; CHOLESTEROL; ADAPTATION; SELECTION; SEQUENCE;

D O I：

10.1126/sciadv.abm5944

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochemistry and microbiome makeup. Our results suggest that distinct demographic and environmental conditions have shaped the dingo genome. In contrast, artificial human selection has likely shaped the genomes of domestic breed dogs after divergence from the dingo.

引用

页数：14

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