Lasiodiplodins from mangrove endophytic fungus Lasiodiplodia sp 318#

被引：21
|
作者：
Li, Jing [1 ]
Xue, Yanyu [2 ]
Yuan, Jie [3 ]
Lu, Yongjun [4 ]
Zhu, Xun [3 ]
Lin, Yongcheng [2 ]
Liu, Lan [1 ]
机构：
[1] Sun Yat Sen Univ, Sch Marine Sci, Guangzhou 510006, Guangdong, Peoples R China
[2] Sun Yat Sen Univ, Sch Chem & Chem Engn, Guangzhou 510275, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Zhongshan Med Coll, Guangzhou 510800, Peoples R China
[4] Sun Yat Sen Univ, Sch Life Sci, Guangzhou 510275, Guangdong, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2016年 / 30卷 / 07期
基金：
美国国家科学基金会;
关键词：
endophytic fungus; lasiodiplodins; cytotoxic activity;
D O I：
10.1080/14786419.2015.1062762
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Four new lasiodiplodins (1-4), together with three known analogues, have been isolated from a mangrove endophytic fungus, Lasiodiplodia sp. 318#. Their structures were elucidated by spectroscopic techniques. Cytotoxic activities of compounds 1-7 were evaluated in vitro against human cancer lines THP1, MDA-MB-435, A549, HepG2 and HCT-116. Compound 4 exhibited moderate cytotoxic activities.
引用
收藏
页码：755 / 760
页数：6
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