Human papillomavirus molecular biology

被引:136
|
作者
Harden, Mallory E. [1 ,2 ]
Munger, Karl [2 ]
机构
[1] Harvard Med Sch, Div Med Sci, Program Virol, Boston, MA 02115 USA
[2] Tufts Univ, Sch Med, Dept Dev Mol & Chem Biol, Boston, MA 02111 USA
关键词
Human papillomavirus; Cervical cancer; Oncogene; Tumor suppressor; Epithelial differentiation; Vaccine; RISK HUMAN-PAPILLOMAVIRUS; MINOR CAPSID PROTEIN; DNA-DAMAGE RESPONSE; HPV-16/18 AS04-ADJUVANTED VACCINE; E6 ONCOPROTEIN REPRESSES; CERVICAL-CANCER; PARTICLE VACCINE; YOUNG-WOMEN; SUSTAINED EFFICACY; NUCLEAR IMPORT;
D O I
10.1016/j.mrrev.2016.07.002
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码:3 / 12
页数:10
相关论文
共 50 条
  • [21] Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis
    Jaana Rautava
    Stina Syrjänen
    Head and Neck Pathology, 2012, 6 (Suppl 1) : 3 - 15
  • [22] Biology of Human Papillomavirus Infections in Head and Neck Carcinogenesis
    Rautava, Jaana
    Syrjanen, Stina
    HEAD & NECK PATHOLOGY, 2012, 6 (01): : S3 - S15
  • [23] Current status and molecular biology of human papillomavirus-independent gastric-type adenocarcinoma of the cervix
    Nishio, Shin
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2023, 49 (04) : 1106 - 1113
  • [24] Hunan papillomavirus and head and neck cancer: Epidemiology and molecular biology
    McKaig, RG
    Baric, RS
    Olshan, AF
    HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, 1998, 20 (03): : 250 - 265
  • [25] A MOLECULAR PORTRAIT OF HUMAN PAPILLOMAVIRUS CARCINOGENESIS
    BROKER, TR
    CHOW, LT
    CHIN, MT
    RHODES, CR
    WOLINSKY, SM
    WHITBECK, A
    STOLER, MH
    MOLECULAR DIAGNOSTICS OF HUMAN CANCER, 1989, 7 : 197 - 208
  • [26] Molecular detection and genotyping of human papillomavirus
    del Rosario-Reves, J
    Matias, RR
    Natividad, FF
    JOURNAL OF CLINICAL VIROLOGY, 2003, 28 : S101 - S101
  • [27] Simplifying the molecular mechanisms of human papillomavirus
    Saunders, NA
    Frazer, IH
    DERMATOLOGIC CLINICS, 1998, 16 (04) : 823 - +
  • [28] Molecular biology of human gliomas
    Bansal, Krishan
    Liang, Muh Lii
    Rutka, James T.
    TECHNOLOGY IN CANCER RESEARCH & TREATMENT, 2006, 5 (03) : 185 - 194
  • [29] The molecular biology of human caliciviruses
    Clarke, IN
    Lambden, PR
    GASTROENTERITIS VIRUSES, 2001, 238 : 180 - 196
  • [30] MOLECULAR BIOLOGY OF HUMAN MILK
    VAIDYA, A
    SCIENCE, 1973, 180 (4087) : 776 - &