Human papillomavirus molecular biology

被引：136
|
作者：
Harden, Mallory E. [1 ,2 ]
Munger, Karl [2 ]
机构：
[1] Harvard Med Sch, Div Med Sci, Program Virol, Boston, MA 02115 USA
[2] Tufts Univ, Sch Med, Dept Dev Mol & Chem Biol, Boston, MA 02111 USA
来源：
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH | 2017年 / 772卷
关键词：
Human papillomavirus; Cervical cancer; Oncogene; Tumor suppressor; Epithelial differentiation; Vaccine; RISK HUMAN-PAPILLOMAVIRUS; MINOR CAPSID PROTEIN; DNA-DAMAGE RESPONSE; HPV-16/18 AS04-ADJUVANTED VACCINE; E6 ONCOPROTEIN REPRESSES; CERVICAL-CANCER; PARTICLE VACCINE; YOUNG-WOMEN; SUSTAINED EFFICACY; NUCLEAR IMPORT;
D O I：
10.1016/j.mrrev.2016.07.002
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Human papillomaviruses are small DNA viruses with a tropism for squamous epithelia. A unique aspect of human papillomavirus molecular biology involves dependence on the differentiation status of the host epithelial cell to complete the viral lifecycle. A small group of these viruses are the etiologic agents of several types of human cancers, including oral and anogenital tract carcinomas. This review focuses on the basic molecular biology of human papillomaviruses. (C) 2016 Elsevier B.V. All rights reserved.
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收藏
页码：3 / 12
页数：10
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