Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases

被引：16

作者：

Numakawa, Tadahiro ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 16期

关键词：

neurodegenerative diseases; BDNF; TrkB; natural compounds; neuroprotection; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; EXPRESSION; FLAVONOIDS; SURVIVAL; PATHWAY; MODELS; RATS;

D O I：

10.4103/1673-5374.139474

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It has been suggested that altered levels/function of brain-derived neurotrophic factor (BDNF) play a role in the pathophysiology of neurodegenerative diseases including Alzheimer's disease. BDNF positively contributes to neural survival and synapse maintenance via stimulating its high affinity receptor TrkB, making upregulation of BDNF and/or activation of BDNF-related intracellular signaling an attractive approach to treating neurodegenerative diseases. In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.

引用

页码：1506 / 1508

页数：3

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