Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases

被引：16
|
作者：
Numakawa, Tadahiro [1 ]
机构：
[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan
来源：
NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 16期
关键词：
neurodegenerative diseases; BDNF; TrkB; natural compounds; neuroprotection; HUNTINGTONS-DISEASE; ALZHEIMERS-DISEASE; EXPRESSION; FLAVONOIDS; SURVIVAL; PATHWAY; MODELS; RATS;
D O I：
10.4103/1673-5374.139474
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
It has been suggested that altered levels/function of brain-derived neurotrophic factor (BDNF) play a role in the pathophysiology of neurodegenerative diseases including Alzheimer's disease. BDNF positively contributes to neural survival and synapse maintenance via stimulating its high affinity receptor TrkB, making upregulation of BDNF and/or activation of BDNF-related intracellular signaling an attractive approach to treating neurodegenerative diseases. In this short review, I briefly introduce small natural compounds such as flavonoids that successfully increase activation of the BDNF system and discuss their beneficial effects against neurodegeneration.
引用
收藏
页码：1506 / 1508
页数：3
相关论文
共 50 条
  • [1] Possible protective action of neurotrophic factors and natural compounds against common neurodegenerative diseases
    Tadahiro Numakawa
    Neural Regeneration Research, 2014, 9 (16) : 1506 - 1508
  • [2] Neurotrophic factors in the treatment of neurodegenerative diseases
    Saarma, M.
    EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2007, 32 (01) : S3 - S3
  • [3] Novel neurotrophic factors for the treatment of neurodegenerative diseases
    Saarma, M.
    EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2009, 19 : S128 - S129
  • [4] Therapeutic Potential of Neurotrophic Factors in Neurodegenerative Diseases
    Yossef S. Levy
    Yossi Gilgun-Sherki
    Eldad Melamed
    Daniel Offen
    BioDrugs, 2005, 19 : 97 - 127
  • [5] Therapeutic potential of neurotrophic factors in neurodegenerative diseases
    Levy, YS
    Gilgun-Sherki, Y
    Melamed, E
    Offen, D
    BIODRUGS, 2005, 19 (02) : 97 - 127
  • [6] NEUROTROPHIC FACTORS AND NEURODEGENERATIVE DISEASES: A DELIVERY ISSUE
    Ruozi, B.
    Belletti, D.
    Bondioli, L.
    De Vita, A.
    Forni, F.
    Vandelli, M. A.
    Tosi, G.
    NEW PERSPECTIVES OF CENTRAL NERVOUS SYSTEM INJURY AND NEUROPROTECTION, 2012, 102 : 207 - 247
  • [7] Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases
    Marino, Attilio
    Battaglini, Matteo
    Moles, Nadia
    Ciofani, Gianni
    ACS OMEGA, 2022, : 25974 - 25990
  • [8] Natural Products and Their Bioactive Compounds: Neuroprotective Potentials against Neurodegenerative Diseases
    Sairazi, Nur Shafika Mohd
    Sirajudeen, K. N. S.
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020
  • [9] Identification of Natural Compounds against Neurodegenerative Diseases Using In Silico Techniques
    Ivanova, Larisa
    Karelson, Mati
    Dobchev, Dimitar A.
    MOLECULES, 2018, 23 (08):
  • [10] THE FUTURE FOR NEUROTROPHIC FACTORS AS THERAPEUTIC AGENTS IN NEURODEGENERATIVE DISEASES
    HENDERSON, C
    M S-MEDECINE SCIENCES, 1995, 11 (08): : 1067 - 1069
12345