Histo-blood group Lewis genotyping from human hairs and blood

被引：8
|
作者：
Yazawa, S
OhKawara, H
Nakajima, T
Hosomi, O
Akamatsu, S
Kishi, K
机构：
[1] GUNMA PREFECTURE POLICE HQ, SCI CRIME LAB, MAEBASHI, GUMMA 371, JAPAN
[2] OTSUKA PHARMACEUT CO LTD, DIV DIAGNOST, TOKUSHIMA 77101, JAPAN
来源：
JAPANESE JOURNAL OF HUMAN GENETICS | 1996年 / 41卷 / 01期
关键词：
Lewis blood group genotyping; PCR-RFLP; non-genuine Lewis-negative phenotypes;
D O I：
10.1007/BF01892625
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The expression of histo-blood group Lewis antigens is determined by the Lewis-type alpha 1-->3/4fucosyltransferase (Le enzyme) encoded by Fuc-TIII gene (Le gene). The genotyping of Le genes by the PCR-RFLP methods established recently and partly modified in this study was found to be useful not only for determining the genuine Lewis blood types of samples such as human hairs and blood stains but also for distinguishing non-genuine Lewis-negative phenotypes frequently observed in pregnant women from genuine ones. The availability of the present PCR-RFLP methods for the paternity tests was also discussed.
引用
收藏
页码：177 / 188
页数：12
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