Opinion -: Microtubule-organizing centres:: a re-evaluation

被引：304
|
作者：
Luders, Jens
Stearns, Tim [1 ]
机构：
[1] Stanford Univ, Dept Biol Sci, Sch Med, Stanford, CA 94305 USA
[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2007年 / 8卷 / 02期
关键词：
D O I：
10.1038/nrm2100
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The number, length, distribution and polarity of microtubules are largely controlled by microtubule-organizing centres, which nucleate and anchor microtubule minus ends in a process that requires gamma-tubulin. Here we discuss recent evidence indicating that gamma-tubulin-dependent formation of new microtubules is not restricted to conventional microtubule- organizing centres. These findings suggest that the spatio-temporal control of microtubule nucleation is more complex than previously thought, leading us to a re-evaluation of the concept of the microtubule- organizing center.
引用
收藏
页码：161 / 167
页数：7
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