In response to the global educational reform the American Community School of Athens (ACS Athens) Greece has developed its own education paradigm, Morfosis which is defined within the 21st century framework, as a holistic, meaningful, and harmonious educational experience, guided by ethos. The vehicle to implement Morfosis, is the i(2)Flex (isquareFlex), a non-traditional learning methodology, organically developed by the ACS Athens community of learners. i(2)Flex integrates face-to-face and internet-based instruction with faculty-guided, student independent learning, and aims aat developing higher order cognitive skills within a learning design framework that is flexible in terms of time, pace, place, and/or mode. Ultimately, i(2)Flex aims at developing students' 21st century skills, while also helping them successfully prepare for their higher education studies and their future careers.