Influence of Sustained Low-Efficiency Dialysis Treatment on Isavuconazole Plasma Levels in Critically Ill Patients

被引：13

作者：

Lahmer, Tobias ^{[1
]}

Baires, Gonzalo Batres ^{[1
]}

Heilmaier, Markus ^{[1
]}

Schmid, Roland M. ^{[1
]}

Soergel, Fritz ^{[2
,3
]}

Kinzig, Martina ^{[2
]}

Huber, Wolfgang ^{[1
]}

Mayr, Ulrich ^{[1
]}

Rasch, Sebastian ^{[1
]}

机构：

[1] Techn Univ Munich, Klinikum Rechts Isar, Klin & Poliklin Innere Med 2, Munich, Germany

[2] Inst Biomed & Pharmaceut Res IBMP, Nurnberg, Germany

[3] Univ Duisburg Essen, Fac Med, Inst Pharmacol, Essen, Germany

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 11期

关键词：

isavuconazole; SLED; critically ill; therapeutic drug monitoring; invasive aspergillosis; ASPERGILLOSIS; DISEASE; GUIDELINES;

D O I：

10.1128/AAC.01162-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Isavuconazole plasma concentrations were measured before and after sustained low-efficiency dialysis (SLED) treatment in 22 critically ill adult patients with probable invasive aspergillosis and underlying hematological malignancies. Isavuconazole levels were significantly lower after SLED treatment (5.73 versus 3.36 mu g/ml; P < 0.001). However, even after SLED treatment, isavuconazole concentrations exceeded the in vivo MICs for several relevant Aspergillus species.

引用

页数：4

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