Influence of Sustained Low-Efficiency Dialysis Treatment on Isavuconazole Plasma Levels in Critically Ill Patients

被引：13
|
作者：
Lahmer, Tobias [1 ]
Baires, Gonzalo Batres [1 ]
Heilmaier, Markus [1 ]
Schmid, Roland M. [1 ]
Soergel, Fritz [2 ,3 ]
Kinzig, Martina [2 ]
Huber, Wolfgang [1 ]
Mayr, Ulrich [1 ]
Rasch, Sebastian [1 ]
机构：
[1] Techn Univ Munich, Klinikum Rechts Isar, Klin & Poliklin Innere Med 2, Munich, Germany
[2] Inst Biomed & Pharmaceut Res IBMP, Nurnberg, Germany
[3] Univ Duisburg Essen, Fac Med, Inst Pharmacol, Essen, Germany
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 11期
关键词：
isavuconazole; SLED; critically ill; therapeutic drug monitoring; invasive aspergillosis; ASPERGILLOSIS; DISEASE; GUIDELINES;
D O I：
10.1128/AAC.01162-19
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Isavuconazole plasma concentrations were measured before and after sustained low-efficiency dialysis (SLED) treatment in 22 critically ill adult patients with probable invasive aspergillosis and underlying hematological malignancies. Isavuconazole levels were significantly lower after SLED treatment (5.73 versus 3.36 mu g/ml; P < 0.001). However, even after SLED treatment, isavuconazole concentrations exceeded the in vivo MICs for several relevant Aspergillus species.
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页数：4
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